Molecular structure of 8-iso Prostaglandin E2-d4, CAS Number: 27415-25-4 (unlabeled)
8-iso Prostaglandin E2-d4 (CAS 27415-25-4 (unlabeled))
Alternate Names:
8-epi PGE2-d4; 8-iso PGE2-d4
Application:
8-iso Prostaglandin E2-d4 is labeled version of 8-iso PGE2 with vasoconstriciton & vasodilation activities
CAS Number:
27415-25-4 (unlabeled)
Molecular Weight:
356.5
Molecular Formula:
C20H28D4O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
8-iso Prostaglandin E2-d4 (8-iso PGE2-d4) contains four deuterium atoms at the hydroxyethyl 3, 3′,4, and 4′ positions. It is intended for use as an internal standard for quantification of 8-iso PGE2 by GC- or LC-mass spectrometry. 8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation(1). It is a potent renal vasoconstrictor in the rat(1,2). 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 µM(3). When infused into the renal artery of the rat at a concentration of 4 mg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure(1).
8-iso Prostaglandin E2-d4 (CAS 27415-25-4 (unlabeled)) References
- Vasodilatory and electrophysiological actions of 8-iso-prostaglandin E2 in porcine coronary artery. | Zhang, Y., et al. 2003. J Pharmacol Exp Ther. 305: 1054-60. PMID: 12626646
- Effects of 8-iso-prostaglandin E2 and 8-iso-prostaglandin F2 alpha on the release of noradrenaline from the isolated rat stomach. | Nakamura, K., et al. 2003. Eur J Pharmacol. 470: 73-8. PMID: 12787833
- Vasoconstrictor effects of 8-iso-prostaglandin E2 and 8-iso-prostaglandin F(2alpha) on human umbilical vein. | Daray, FM., et al. 2004. Eur J Pharmacol. 499: 189-95. PMID: 15363966
- The bronchodilators 8-iso-prostaglandin E2 and prostaglandin E2 induce K+ current suppression via thromboxane A2 receptors in porcine tracheal smooth muscle. | Helli, PB., et al. 2004. Eur J Pharmacol. 501: 179-84. PMID: 15464076
- Actions of the E2-isoprostane, 8-ISO-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: additional evidence for the existence of a unique isoprostane receptor. | Longmire, AW., et al. 1994. Prostaglandins. 48: 247-56. PMID: 7878192
- Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes. | Morrow, JD., et al. 1994. J Biol Chem. 269: 4317-26. PMID: 8307999
- Isoprostanes: free radical-generated prostaglandins with constrictor effects on cerebral arterioles. | Hoffman, SW., et al. 1997. Stroke. 28: 844-9. PMID: 9099206
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-iso Prostaglandin E2-d4, 25 µg | sc-221137 | 25 µg | $158.00 | |||
8-iso Prostaglandin E2-d4, 50 µg | sc-221137A | 50 µg | $304.00 |