Molecular structure of 8-iso Prostaglandin E2, CAS Number: 27415-25-4
8-iso Prostaglandin E2 (CAS 27415-25-4)
Alternate Names:
8-epi PGE2; 8-epi PGE2
Application:
8-iso Prostaglandin E2 is an epimer of PGE2 - a potent renal vasoconstrictor, bronchodilator, and smooth muscle relaxant
CAS Number:
27415-25-4
Molecular Weight:
352.5
Molecular Formula:
C20H32O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
8-iso Prostaglandin E2 is the epimer at C8 of PGE2 (sc-201225) and is one of several isoprostanes produced from arachidonic acid (sc-200770) during lipid peroxidation. This compound has been shown to be a potent renal vasoconstrictor in the rat, and to inhibit U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 μM, respectively. Interestingly it has been reported that this compound also relaxes smooth muscle and has been shown to cause vasodilation of porcine coronary artery. Furthermore, 8-iso Prostaglandin E2 demonstrated brochodilation in porcine tracheal smooth muscle via K+ current suppression caused by activation of thromboxane A2 receptors.
8-iso Prostaglandin E2 (CAS 27415-25-4) References
- Vasodilatory and electrophysiological actions of 8-iso-prostaglandin E2 in porcine coronary artery. | Zhang, Y., et al. 2003. J Pharmacol Exp Ther. 305: 1054-60. PMID: 12626646
- Effects of 8-iso-prostaglandin E2 and 8-iso-prostaglandin F2 alpha on the release of noradrenaline from the isolated rat stomach. | Nakamura, K., et al. 2003. Eur J Pharmacol. 470: 73-8. PMID: 12787833
- Vasoconstrictor effects of 8-iso-prostaglandin E2 and 8-iso-prostaglandin F(2alpha) on human umbilical vein. | Daray, FM., et al. 2004. Eur J Pharmacol. 499: 189-95. PMID: 15363966
- The bronchodilators 8-iso-prostaglandin E2 and prostaglandin E2 induce K+ current suppression via thromboxane A2 receptors in porcine tracheal smooth muscle. | Helli, PB., et al. 2004. Eur J Pharmacol. 501: 179-84. PMID: 15464076
- Eicosanoids and Eosinophilic Inflammation of Airways in Stable COPD. | Celejewska-Wójcik, N., et al. 2021. Int J Chron Obstruct Pulmon Dis. 16: 1415-1424. PMID: 34079245
- Dynamic alterations in metabolomics and transcriptomics associated with intestinal fibrosis in a 2,4,6-trinitrobenzene sulfonic acid-induced murine model. | Wu, J., et al. 2023. J Transl Med. 21: 554. PMID: 37592304
- Exploring the Potential Role of Metabolomics in COPD: A Concise Review. | Tirelli, C., et al. 2024. Cells. 13: PMID: 38534319
- Actions of the E2-isoprostane, 8-ISO-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: additional evidence for the existence of a unique isoprostane receptor. | Longmire, AW., et al. 1994. Prostaglandins. 48: 247-56. PMID: 7878192
- Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes. | Morrow, JD., et al. 1994. J Biol Chem. 269: 4317-26. PMID: 8307999
- Isoprostanes: free radical-generated prostaglandins with constrictor effects on cerebral arterioles. | Hoffman, SW., et al. 1997. Stroke. 28: 844-9. PMID: 9099206
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-iso Prostaglandin E2, 500 µg | sc-205172 | 500 µg | $52.00 | |||
8-iso Prostaglandin E2, 5 mg | sc-205172A | 5 mg | $420.00 |