Date published: 2026-4-25

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8-iso Prostaglandin E1 (CAS 21003-46-3)

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Application:
8-iso Prostaglandin E1 is an isoprostane with potency similar to PGF2α
CAS Number:
21003-46-3
Molecular Weight:
354.5
Molecular Formula:
C20H34O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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8-iso Prostaglandin E1 is a compound that functions as a lipid mediator in cellular signaling pathways. It acts as a potent vasodilator, influencing the relaxation of smooth muscle cells in blood vessels. At the molecular level, it interacts with specific prostaglandin receptors, leading to the activation of intracellular signaling. This activation ultimately results in the modulation of various physiological processes, including inflammation, immune response, and vascular tone regulation. 8-iso Prostaglandin E1 also plays a role in the regulation of platelet aggregation and blood clot formation. Its mechanism of action involves binding to specific receptors on target cells, triggering a series of biochemical events that contribute to some cellular response. In experimental applications, 8-iso Prostaglandin E1 is utilized to investigate the molecular mechanisms underlying vascular function, inflammation, and related physiological processes.


8-iso Prostaglandin E1 (CAS 21003-46-3) References

  1. Influence of isoprostanes on vasoconstrictor effects of noradrenaline and angiotensin II.  |  Sametz, W., et al. 1999. Eur J Pharmacol. 378: 47-55. PMID: 10478564
  2. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.  |  Morrow, JD., et al. 1990. Proc Natl Acad Sci U S A. 87: 9383-7. PMID: 2123555
  3. The 8-isoprostaglandins: evidence for eight compounds in human semen.  |  Taylor, PL. 1979. Prostaglandins. 17: 259-67. PMID: 441435
  4. Effects of 8-isoprostaglandin E1 on the systemic and pulmonary circulations in dogs.  |  Nakano, J. and Kessinger, JM. 1970. Proc Soc Exp Biol Med. 133: 1314-7. PMID: 5440421
  5. Mass spectrometric analysis of F2-isoprostanes: markers and mediators in human disease  |  Schwedhelm, E., Benndorf, R. A., Boger, R. H., & Tsikas, D. 2007. Current Pharmaceutical Analysis. 3(1): 39-51.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

8-iso Prostaglandin E1, 500 µg

sc-223752
500 µg
$46.00

8-iso Prostaglandin E1, 1 mg

sc-223752A
1 mg
$65.00