8-iso-17-phenyl trinor Prostaglandin F2α
Molecular Weight:
388.5
Molecular Formula:
C23H32O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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8-iso-17-phenyl trinor Prostaglandin F2α (8-iso-17-phenyl trinor PGF2α) is the C-8 epimer of bimatoprost (free acid), a metabolically stable analog of PGF2α. Bimatoprost (free acid) binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α.1 At the rat recombinant FP receptor expressed in CHO cells bimatoprost inhibits PGF2α binding with a Ki of 1.1 nM.2 There are no published studies of the pharmacological properties of 8-iso-17-phenyl trinor PGF2α.
8-iso-17-phenyl trinor Prostaglandin F2α References
1 Balapure, A.K., Rexroad, C.E., Kawada, K., et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptor. Biochem Pharmacol 38 2375-2381 (1989). 2 Lake, S., Gullberg, H., Wahlqvist, J., et al. Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptor. FEBS Lett 355 317-325 (1994).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-iso-17-phenyl trinor Prostaglandin F2α, 1 mg | sc-221144 | 1 mg | $176.00 | |||
8-iso-17-phenyl trinor Prostaglandin F2α, 5 mg | sc-221144A | 5 mg | $793.00 |