8-iso-15-keto Prostaglandin F2α
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8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in monkeys, rabbits, and humans. 8-isoprostane (8-iso PGF2α) is a prostaglandin-like product of non-specific lipid peroxidation(1). In both humans and monkeys, exogenously infused 8-iso PGF2α is converted to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation(2). A similar pattern is observed when tritiated 8-iso PGF2α is infused into rabbits(3). Early in the infusion (within 1-2 minutes) 8-iso -15-keto PGF2α was a major component of the metabolite profile, which was mostly of unmetabolized 8-iso PGF2α. 8-iso -15-keto PGF2α is a vasoconstrictor when tested on the rat isolated thoracic aorta, acting via the TP (thromboxane) receptor(4).
8-iso-15-keto Prostaglandin F2α References
- Characterization of the effects of isoprostanes on platelet aggregation in human whole blood. | Cranshaw, JH., et al. 2001. Br J Pharmacol. 132: 1699-706. PMID: 11309241
- A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. | Morrow, JD., et al. 1990. Proc Natl Acad Sci U S A. 87: 9383-7. PMID: 2123555
- dLLME-μSPE extraction coupled to HPLC-ESI-MS/MS for the determination of F2α-IsoPs in human urine. | Fanti, F., et al. 2020. J Pharm Biomed Anal. 186: 113302. PMID: 32353681
- Integration of ultra-high-pressure liquid chromatography-tandem mass spectrometry with machine learning for identifying fatty acid metabolite biomarkers of ischemic stroke. | Zhang, L., et al. 2020. Chem Commun (Camb). 56: 6656-6659. PMID: 32409805
- Transkingdom interactions between Lactobacilli and hepatic mitochondria attenuate western diet-induced diabetes. | Rodrigues, RR., et al. 2021. Nat Commun. 12: 101. PMID: 33397942
- Maternal exposure to ambient PM2.5 perturbs the metabolic homeostasis of maternal serum and placenta in mice. | Tao, S., et al. 2023. Environ Res. 216: 114648. PMID: 36341790
- Central administration of Dapagliflozin alleviates a hypothalamic neuroinflammatory signature and changing tubular lipid metabolism in type 2 diabetic nephropathy by upregulating MCPIP1. | Da, J., et al. 2023. Biomed Pharmacother. 168: 115840. PMID: 37931516
- Metabolism of 8-iso-prostaglandin F2alpha. | Basu, S. 1998. FEBS Lett. 428: 32-6. PMID: 9645469
- Identification and measurement of endogenous beta-oxidation metabolites of 8-epi-Prostaglandin F2alpha. | Chiabrando, C., et al. 1999. J Biol Chem. 274: 1313-9. PMID: 9880501
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-iso-15-keto Prostaglandin F2α, 100 µg | sc-221143 | 100 µg | $20.00 | |||
8-iso-15-keto Prostaglandin F2α, 500 µg | sc-221143A | 500 µg | $78.00 |