Molecular structure of 8-iso-15-keto Prostaglandin E2
8-iso-15-keto Prostaglandin E2
Application:
8-iso-15-keto Prostaglandin E2 is an isoprostane produced by the free radical peroxidative degradation of membrane lipids
Molecular Weight:
350.5
Molecular Formula:
C20H30O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
8-iso-15-keto Prostaglandin E2 (8-iso-15-keto PGE2) is an isoprostane, a member of a large family of biomarkers produced by the free radical peroxidative degradation of membrane lipids. This compound is the putative first metabolite of the biologically active compound, 8-iso PGE2 (sc-205172)via the 15-hydroxy PGDH pathway. There are no published studies of the biological action of 8-iso-15-keto Prostaglandin E2, however, these prostaglandin analogues are integral for structure-activity studies used in the deconvolution of these complex biochemical pathways.
8-iso-15-keto Prostaglandin E2 References
- A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. | Morrow, JD., et al. 1990. Proc Natl Acad Sci U S A. 87: 9383-7. PMID: 2123555
- Preliminary case control study to establish the correlation between novel peroxidation biomarkers in cord serum and the severity of hypoxic ischemic encephalopathy. | Chafer-Pericas, C., et al. 2016. Free Radic Biol Med. 97: 244-249. PMID: 27296840
- Development and application of a UHPLC-MS/MS metabolomics based comprehensive systemic and tissue-specific screening method for inflammatory, oxidative and nitrosative stress. | Schoeman, JC., et al. 2018. Anal Bioanal Chem. 410: 2551-2568. PMID: 29497765
- Rotating-disc micro-solid phase extraction of F2-isoprostanes from maternal and cord plasma by using oxidized buckypaper as sorbent membrane. | Tomai, P., et al. 2019. J Chromatogr A. 1586: 30-39. PMID: 30563692
- Multiple 'omics'-analysis reveals the role of prostaglandin E2 in Hirschsprung's disease. | Tang, W., et al. 2021. Free Radic Biol Med. 164: 390-398. PMID: 33465467
- Consumption of Supplementary Inulin Modulates Milk Microbiota and Metabolites in Dairy Cows with Subclinical Mastitis. | Wang, Y., et al. 2022. Appl Environ Microbiol. 88: e0205921. PMID: 34936838
- Integrated fecal microbiome and metabolome analysis explore the link between polystyrene nanoplastics exposure and male reproductive toxicity in mice. | Fu, X., et al. 2023. Environ Toxicol. 38: 1277-1291. PMID: 36880397
- Alpinia katsumadai Hayata Volatile Oil Is Effective in Treating 5-Fluorouracil-Induced Mucositis by Regulating Gut Microbiota and Modulating the GC/GR Pathway and the mPGES-1/PGE2/EP4 Pathways. | Liu, D., et al. 2023. J Agric Food Chem. 71: 15156-15169. PMID: 37800952
- Actions of the E2-isoprostane, 8-ISO-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: additional evidence for the existence of a unique isoprostane receptor. | Longmire, AW., et al. 1994. Prostaglandins. 48: 247-56. PMID: 7878192
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-iso-15-keto Prostaglandin E2, 100 µg | sc-223753 | 100 µg | $19.00 | |||
8-iso-15-keto Prostaglandin E2, 500 µg | sc-223753A | 500 µg | $84.00 |