Molecular structure of 8-iso-13,14-dihydro-15-keto Prostaglandin F2α, CAS Number: 191919-02-5
8-iso-13,14-dihydro-15-keto Prostaglandin F2α (CAS 191919-02-5)
Application:
8-iso-13,14-dihydro-15-keto Prostaglandin F2α is a PG-like product of non-specific lipid peroxidation
CAS Number:
191919-02-5
Molecular Weight:
354.5
Molecular Formula:
C20H34O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
8-iso PGF2α is a PG-like product of non-specific lipid peroxidation.2 In both humans and monkeys, exogenously infused 8-isoprostane is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation.1 A similar pattern is observed when tritiated 8-isoprostane is infused into rabbits.3 8-iso-13,14-dihydro-15-keto PGF2α weakly inhibits the U-46619 or collagen-induced aggregation of human platelets, although a number of the E-series isoprostanes are much more potent in this assay.4
8-iso-13,14-dihydro-15-keto Prostaglandin F2α (CAS 191919-02-5) References
- Characterization of the effects of isoprostanes on platelet aggregation in human whole blood. | Cranshaw, JH., et al. 2001. Br J Pharmacol. 132: 1699-706. PMID: 11309241
- A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. | Morrow, JD., et al. 1990. Proc Natl Acad Sci U S A. 87: 9383-7. PMID: 2123555
- Metabolism of 8-iso-prostaglandin F2alpha. | Basu, S. 1998. FEBS Lett. 428: 32-6. PMID: 9645469
- Identification and measurement of endogenous beta-oxidation metabolites of 8-epi-Prostaglandin F2alpha. | Chiabrando, C., et al. 1999. J Biol Chem. 274: 1313-9. PMID: 9880501
- Chemical and biological properties of frequent screening hits[J]. | Che J, King F J, Zhou B,. 2012. Journal of chemical information and modeling,., 52(4):: 913-926.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-iso-13,14-dihydro-15-keto Prostaglandin F2α, 50 µg | sc-205176 | 50 µg | $73.00 | |||
8-iso-13,14-dihydro-15-keto Prostaglandin F2α, 100 µg | sc-205176A | 100 µg | $105.00 |