Date published: 2025-10-15

1-800-457-3801

SCBT Portrait Logo
Seach Input

8-Hydroxy Amoxapine (CAS 61443-78-5)

0.0(0)
Write a reviewAsk a question

See product citations (1)

Alternate Names:
2-Chloro-11-(1-piperazinyl)-dibenz[b,f][1,4]oxazepin-8-ol; 8-Hydroxyamoxapin
Application:
8-Hydroxy Amoxapine is a metabolite of Amoxapine
CAS Number:
61443-78-5
Molecular Weight:
329.78
Molecular Formula:
C17H16ClN3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

8-Hydroxy Amoxapine is a metabolite of Amoxapine. The addition of a hydroxy group at the eighth position of the molecule signifies a phase I metabolic reaction, typically involving the introduction of a functional group to increase the solubility of the compound, facilitating its excretion. In biochemical research, studying metabolites such as 8-Hydroxy Amoxapine is important for several reasons. First, it helps in elucidating the metabolic pathways of the parent, identifying the enzymes involved in its metabolism. 8-Hydroxy amoxapine has been employed as a representative compound to examine the impact of oxidative stress on the body and explore the biochemical and physiological consequences associated with amoxapine.


8-Hydroxy Amoxapine (CAS 61443-78-5) References

  1. Metabolites and bioequivalence: past and present.  |  Jackson, AJ., et al. 2004. Clin Pharmacokinet. 43: 655-72. PMID: 15244496
  2. Investigation of the disposition of loxapine, amoxapine and their hydroxylated metabolites in different brain regions, CSF and plasma of rat by LC-MS/MS.  |  Wong, YC., et al. 2012. J Pharm Biomed Anal. 58: 83-93. PMID: 21993198
  3. Brain disposition and catalepsy after intranasal delivery of loxapine: role of metabolism in PK/PD of intranasal CNS drugs.  |  Wong, YC. and Zuo, Z. 2013. Pharm Res. 30: 2368-84. PMID: 23739987
  4. Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants.  |  Eap, CB., et al. 2021. World J Biol Psychiatry. 22: 561-628. PMID: 33977870
  5. Interaction of amoxapine with muscarinic cholinergic receptors: an in vitro assessment.  |  Coupet, J., et al. 1985. Eur J Pharmacol. 112: 231-5. PMID: 4029261

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

8-Hydroxy Amoxapine, 1 mg

sc-210681
1 mg
$388.00