Molecular structure of 8-Hydroxy-2′-deoxyguanosine, CAS Number: 88847-89-6
8-Hydroxy-2′-deoxyguanosine (CAS 88847-89-6)
See product citations (14)
Alternate Names:
8-Oxo-dG
Application:
8-Hydroxy-2′-deoxyguanosine is a useful marker for indication of DNA damage via mutagenesis and carcinogenesis
CAS Number:
88847-89-6
Molecular Weight:
283.24
Molecular Formula:
C10H13N5O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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8-Hydroxy-2′-deoxyguanosine (8-Oxo-dG) is a marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis. It is produced by oxidative damage of DNA by reactive oxygen and nitrogen species, including hydroxyl radical and peroxynitrite. It serves as a critical biomarker of oxidative stress and carcinogenesis. Researchers use techniques such as high-performance liquid chromatography (HPLC), enzyme-linked immunosorbent assay (ELISA), and mass spectrometry to measure and quantify the levels of 8-Hydroxy-2′-deoxyguanosine in biological samples. Studying this compound helps researchers understand the impact of oxidative stress on DNA integrity, cellular function, and disease development.
8-Hydroxy-2′-deoxyguanosine (CAS 88847-89-6) References
- 8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. | Valavanidis, A., et al. 2009. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 27: 120-39. PMID: 19412858
- 8-hydroxy-2'-deoxyguanosine and cardiovascular disease: a systematic review. | Kroese, LJ. and Scheffer, PG. 2014. Curr Atheroscler Rep. 16: 452. PMID: 25252787
- Competitive Multiple-Mechanism-Driven Electrochemiluminescent Detection of 8-Hydroxy-2'-deoxyguanosine. | Lv, Y., et al. 2018. J Am Chem Soc. 140: 2801-2804. PMID: 29443530
- Ultrasensitive electrochemiluminescence aptasensor for 8-hydroxy-2'-deoxyguanosine detection based on target-induced multi-DNA release and nicking enzyme amplification strategy. | Zhao, RN., et al. 2019. Biosens Bioelectron. 144: 111669. PMID: 31494507
- Detection of 8-Hydroxy-2'-Deoxyguanosine Biomarker with a Screen-Printed Electrode Modified with Graphene. | Varodi, C., et al. 2019. Sensors (Basel). 19: PMID: 31590208
- Prognostic significance of 8-hydroxy-2'-deoxyguanosine in solid tumors: a meta-analysis. | Qing, X., et al. 2019. BMC Cancer. 19: 997. PMID: 31651287
- Prognostic impact of 8-hydroxy-deoxyguanosine and its repair enzyme 8-hydroxy-deoxyguanosine DNA glycosylase in hepatocellular carcinoma. | Yugawa, K., et al. 2020. Pathol Int. 70: 533-541. PMID: 32419286
- Blood-based 8-hydroxy-2'-deoxyguanosine level: A potential diagnostic biomarker for atrial fibrillation. | Li, J., et al. 2021. Heart Rhythm. 18: 271-277. PMID: 33031960
- 8-Hydroxy-2'-Deoxyguanosine as an Oxidative Stress Marker in Insomnia. | Semenova, NV., et al. 2021. Bull Exp Biol Med. 171: 384-387. PMID: 34297292
- High serum 8-hydroxy-2'-deoxyguanosine levels predict DNA damage and aging in professional divers. | Gunes, AE., et al. 2021. Rev Assoc Med Bras (1992). 67: 1701-1705. PMID: 34909901
- Can serum 8-hydroxy-2'-deoxyguanosine levels reflect the severity of pulmonary arterial hypertension? | Coskun, FY., et al. 2021. Rev Assoc Med Bras (1992). 67: 1437-1442. PMID: 35018972
- Follicular fluid 8-Hydroxy-2-Deoxyguanosine (8-OHdG) as biomarker for oxidative stress in intracytoplasmic sperm injection. | Mukheef, MA., et al. 2022. J Med Invest. 69: 112-116. PMID: 35466131
- Induction of 8-hydroxydeoxyguanosine in isolated DNA and HeLa cells exposed to fecapentaene-12: evidence for the involvement of prostaglandin H synthase and iron. | Plummer, SM. and Faux, SP. 1994. Carcinogenesis. 15: 449-53. PMID: 8118927
- Increased 8-hydroxydeoxyguanosine in kidney and liver of rats continuously exposed to copper. | Toyokuni, S. and Sagripanti, JL. 1994. Toxicol Appl Pharmacol. 126: 91-7. PMID: 8184438
- Characterization of singlet oxygen-induced guanine residue damage after photochemical treatment of free nucleosides and DNA. | Kvam, E., et al. 1994. Biochim Biophys Acta. 1217: 9-15. PMID: 8286420
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-Hydroxy-2′-deoxyguanosine, 1 mg | sc-291736 | 1 mg | $72.00 | |||
8-Hydroxy-2′-deoxyguanosine, 5 mg | sc-291736A | 5 mg | $219.00 | |||
8-Hydroxy-2′-deoxyguanosine, 25 mg | sc-291736B | 25 mg | $892.00 |