Date published: 2026-2-8

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8-Chloro-2′-deoxyguanosine (CAS 437715-62-3)

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CAS Number:
437715-62-3
Molecular Weight:
301.69
Molecular Formula:
C10H12ClN5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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8-Chloro-2′-deoxyguanosine is a modified nucleoside that can be incorporated into DNA during replication and transcription. It acts as a chain terminator, preventing further elongation of the DNA strand due to its modified structure. 8-Chloro-2′-Deoxyguanosine can also induce mutations by mispairing with adenine during DNA synthesis, leading to potential errors in the genetic code. 8-Chloro-2′-deoxyguanosine may interfere with the activity of DNA polymerases, affecting their ability to accurately replicate DNA. 8-Chloro-2′-Deoxyguanosine′s mechanism of action involves disrupting the normal processes of DNA replication and transcription, potentially leading to genetic instability and altered gene expression. 8-Chloro-2′-deoxyguanosine plays a role in inducing mutations and interfering with DNA synthesis, making it useful for studying the effects of DNA damage and repair mechanisms in experimental applications.


8-Chloro-2′-deoxyguanosine (CAS 437715-62-3) References

  1. Nicotine-modulated formation of spiroiminodihydantoin nucleoside via 8-oxo-7,8-dihydro-2'-deoxyguanosine in 2'-deoxyguanosine-hypochlorous acid reaction.  |  Suzuki, T. and Ohshima, H. 2002. FEBS Lett. 516: 67-70. PMID: 11959105
  2. Novel products generated from 2'-deoxyguanosine by hypochlorous acid or a myeloperoxidase-H2O2-Cl- system: identification of diimino-imidazole and amino-imidazolone nucleosides.  |  Suzuki, T., et al. 2002. Nucleic Acids Res. 30: 2555-64. PMID: 12034845
  3. Identification of products formed by reaction of 3',5'-di-O-acetyl-2'-deoxyguanosine with hypochlorous acid or a myeloperoxidase-H2O2-Cl- system.  |  Suzuki, T., et al. 2003. Chem Res Toxicol. 16: 382-9. PMID: 12641439
  4. Base pair stability of 8-chloro- and 8-iodo-2'-deoxyguanosine opposite 2'-deoxycytidine: implications regarding the bioactivity of 8-oxo-2'-deoxyguanosine.  |  Hamm, ML., et al. 2005. J Am Chem Soc. 127: 12220-1. PMID: 16131189
  5. Detection of chlorinated DNA and RNA nucleosides by HPLC coupled to tandem mass spectrometry as potential biomarkers of inflammation.  |  Badouard, C., et al. 2005. J Chromatogr B Analyt Technol Biomed Life Sci. 827: 26-31. PMID: 16260376
  6. Chemical and immunochemical detection of 8-halogenated deoxyguanosines at early stage inflammation.  |  Asahi, T., et al. 2010. J Biol Chem. 285: 9282-91. PMID: 20081197
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

8-Chloro-2′-deoxyguanosine, 1 mg

sc-284837
1 mg
$357.00

8-Chloro-2′-deoxyguanosine, 2 mg

sc-284837A
2 mg
$571.00