Molecular structure of 8-Bromoadenosine, CAS Number: 2946-39-6
8-Bromoadenosine (CAS 2946-39-6)
Alternate Names:
6-Amino-8-bromopurine riboside
Application:
8-Bromoadenosine is an adenosine binding inhibitor
CAS Number:
2946-39-6
Molecular Weight:
346.14
Molecular Formula:
C10H12BrN5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
8-Bromoadenosine, an adenosine analogue, can be used for exploring the biochemical and physiological impacts of adenosine. 8-Bromoadenosine is used to study signal transduction pathways, particularly those involving adenosine receptors. By acting as an agonist or antagonist, 8-Bromoadenosine can be used to modulate receptor activity in cell-based assays. In molecular biology, 8-Bromoadenosine is often utilized as a selective agent in the study of nucleic acid metabolism and function. Its incorporation into RNA molecules can affect RNA processing, stability, and interaction with proteins, providing insights into the mechanisms of RNA-mediated cellular processes.
8-Bromoadenosine (CAS 2946-39-6) References
- Synthesis, photochemistry and application of (7-methoxycoumarin-4-yl)methyl-caged 8-bromoadenosine cyclic 3',5'-monophosphate and 8-bromoguanosine cyclic 3',5'-monophosphate photolyzed in the nanosecond time region. | Hagen, V., et al. 1999. J Photochem Photobiol B. 53: 91-102. PMID: 10672534
- 8-bromoadenosine 3':5'-cyclic monophosphate as a promoter of cell division in excised tobacco pith parenchyma tissue. | Wood, HN. and Braun, AC. 1973. Proc Natl Acad Sci U S A. 70: 447-50. PMID: 16592058
- Treatment of intact striatal neurones with cholera toxin or 8-bromoadenosine 3',5'-(cyclic)phosphate decreases the ability of pertussis toxin to ADP-ribosylate the alpha-subunits of inhibitory and other guanine-nucleotide-binding regulatory proteins, Gi and Go. Evidence for two distinct mechanisms. | Maus, M., et al. 1991. Eur J Biochem. 196: 313-20. PMID: 1848817
- On the ability of 8-bromoadenosine triphosphate to support contractility of vertebrate skeletal muscle fibers. | Iwamoto, H. 2008. J Muscle Res Cell Motil. 29: 45-55. PMID: 18615269
- Characterization of the interaction between 8-bromoadenosine with human serum albumin and its analytical application. | Cui, F., et al. 2009. Spectrochim Acta A Mol Biomol Spectrosc. 74: 964-71. PMID: 19775931
- Patterns of human chorionic gonadotropin expression in untreated and 8-bromoadenosine-treated JAR choriocarcinoma cells. | Martell, RE. and Ruddon, RW. 1990. Endocrinology. 126: 2757-64. PMID: 2184024
- Formation of 8-S-L-Cysteinyladenosine from 8-Bromoadenosine and Cysteine. | Suzuki, T., et al. 2018. Chem Pharm Bull (Tokyo). 66: 184-187. PMID: 29386470
- Effects of 8-bromoadenosine 3':5'-cyclic monophosphate on proteolytic enzymes, adhesiveness and lung-colonizing ability of cloned low-metastatic Lewis lung carcinoma cells. | Takenaga, K. 1986. Jpn J Cancer Res. 77: 998-1004. PMID: 3023266
- Different Mechanisms of DNA Radiosensitization by 8-Bromoadenosine and 2'-Deoxy-2'-fluorocytidine Observed on DNA Origami Nanoframe Supports. | Sala, L., et al. 2022. J Phys Chem Lett. 13: 3922-3928. PMID: 35472278
- Interaction between glucocorticoids, 8-bromoadenosine 3',5'-monophosphate, and insulin in regulation of synthesis of carbamoyl-phosphate synthetase I in Reuber hepatoma H-35. | Kitagawa, Y. and Sugimoto, E. 1985. Eur J Biochem. 150: 249-54. PMID: 3894022
- Crystal and molecular structure of 8-bromoguanosine and 8-bromoadenosine, two purine nucleosides in the syn conformation. | Tavale, SS. and Sobell, HM. 1970. J Mol Biol. 48: 109-23. PMID: 5448585
- Studies of nucleosides and nucleotides. XLI. Purine cyclonucleosides. 8. Selective sulfonylation of 8-bromoadenosine derivatives and an alternate synthesis of 8,2'-and 8,3'-S-cyclonucleosides. | Ikehara, M. and Kaneko, M. 1970. Tetrahedron. 26: 4251-9. PMID: 5469477
- Studies on nucleosides and nucleotides. 38. Synthesis of 8-bromoadenosine nucleotides. | Ikehara, M. and Uesugi, S. 1969. Chem Pharm Bull (Tokyo). 17: 348-54. PMID: 5782965
- Cyclic AMP regulation of messenger RNA level of the stimulatory GTP-binding protein Gs alpha. Isoproterenol, forskolin and 8-bromoadenosine 3':5'-cyclic monophosphate increase the level of Gs alpha mRNA in cultured astroglial cells. | Dib, K., et al. 1994. Eur J Biochem. 219: 529-37. PMID: 7508389
- Synthesis of the 2'-deoxy-2'-fluoro and 3'-deoxy-3'-fluoro analogues of 8-bromoadenosine. | Maruyama, T., et al. 1997. Nucleic Acids Symp Ser. 17-8. PMID: 9585977
Inhibitor of:
Olfr791.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-Bromoadenosine, 1 g | sc-221127 | 1 g | $139.00 | |||
8-Bromoadenosine, 5 g | sc-221127A | 5 g | $577.00 |