8-Aza-2,6-diaminopurine sulfate (CAS 65591-11-9)
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8-Aza-2,6-diaminopurine sulfate is an analog of adenine, one of the four nucleobases in DNA, with a nitrogen atom replacing the carbon at the 8-position of the purine ring. In research applications, this compound is used to study nucleic acid interactions, replication, and the effects of base modifications on genetic stability and function. It is particularly useful in investigations of mutagenesis and DNA repair processes because it can pair with both thymine and cytosine, potentially leading to ambiguous base pairing during DNA replication. In biochemical assays, 8-Aza-2,6-diaminopurine sulfate is utilized to probe the specificity of enzymes such as polymerases and nucleases that act on nucleic acids. Additionally, its incorporation into oligonucleotides helps in the study of nucleic acid structure, stability, and dynamics. The sulfate salt form of this compound provides increased solubility, making it more suitable for experimental use in various in vitro systems.
8-Aza-2,6-diaminopurine sulfate (CAS 65591-11-9) References
- Germination requirements of Bacillus macerans spores. | Sacks, LE. and Thompson, PA. 1971. J Bacteriol. 105: 739-46. PMID: 4251279
- Stimulation of Growth of an Adenine-requiring Yeast by Purine Analogues | Takahashi, T., Imai, Y., Okamura, S., & Takahashi, H. 1969. Agricultural and Biological Chemistry. 33(3): 377-383.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-Aza-2,6-diaminopurine sulfate, 500 mg | sc-278639A | 500 mg | $168.00 | |||
8-Aza-2,6-diaminopurine sulfate, 1 g | sc-278639 | 1 g | $250.00 |