Molecular structure of 8-Aminoguanosine, CAS Number: 3868-32-4
8-Aminoguanosine (CAS 3868-32-4)
Alternate Names:
2,8-Diaminoinosine
Application:
8-Aminoguanosine is a potent inhibitor of purine nucleoside phosphorylase
CAS Number:
3868-32-4
Purity:
≥98%
Molecular Weight:
298.26
Molecular Formula:
C10H14N6O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A potent inhibitor of purine nucleoside phosphorylase.
8-Aminoguanosine (CAS 3868-32-4) References
- 8-Aminoguanosine and 8-Aminoguanine Exert Diuretic, Natriuretic, Glucosuric, and Antihypertensive Activity. | Jackson, EK., et al. 2016. J Pharmacol Exp Ther. 359: 420-435. PMID: 27679494
- 8-Aminoguanosine Exerts Diuretic, Natriuretic, and Glucosuric Activity via Conversion to 8-Aminoguanine, Yet Has Direct Antikaliuretic Effects. | Jackson, EK. and Mi, Z. 2017. J Pharmacol Exp Ther. 363: 358-366. PMID: 28928119
- 8-Aminoguanine Induces Diuresis, Natriuresis, and Glucosuria by Inhibiting Purine Nucleoside Phosphorylase and Reduces Potassium Excretion by Inhibiting Rac1. | Jackson, EK., et al. 2018. J Am Heart Assoc. 7: e010085. PMID: 30608204
- Dipyridamole and 8-aminoguanosine inhibition of nucleoside metabolism in rat blood in vitro. | Gilbertsen, RB. and Dong, MK. 1986. Adv Exp Med Biol. 195 Pt A: 575-82. PMID: 3088923
- Effects of 8-aminoguanosine on the toxicity of guanosine and deoxyguanosine for malignant and normal lymphoid cells. | van der Kraan, PM., et al. 1988. J Leukoc Biol. 44: 46-50. PMID: 3164750
- Biochemical pathways of 8-aminoguanine production in Sprague-Dawley and Dahl salt-sensitive rats. | Jackson, EK., et al. 2022. Biochem Pharmacol. 201: 115076. PMID: 35551915
- 8-Aminoinosine and 8-Aminohypoxanthine Inhibit Purine Nucleoside Phosphorylase and Exert Diuretic and Natriuretic Activity. | Jackson, EK., et al. 2022. J Pharmacol Exp Ther. 382: 135-148. PMID: 35609923
- 8-Aminopurines in the Cardiovascular and Renal Systems and Beyond. | Jackson, EK., et al. 2023. Hypertension. 80: 2265-2279. PMID: 37503660
- Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T lymphoblasts. | Kazmers, IS., et al. 1981. Science. 214: 1137-9. PMID: 6795718
- Nucleosides. 5. Synthesis of guanine and formycin B derivatives as potential inhibitors of purine nucleoside phosphorylase. | Chern, JW., et al. 1993. J Med Chem. 36: 1024-31. PMID: 8478902
Inhibitor of:
PNP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-Aminoguanosine, 500 mg | sc-221120 | 500 mg | $347.00 | |||
8-Aminoguanosine, 1 g | sc-221120A | 1 g | $561.00 |