Molecular structure of 8-Aminoguanine, CAS Number: 28128-41-8
8-Aminoguanine (CAS 28128-41-8)
Alternate Names:
2,8-Diamino-1,9-dihydro-purin-6-one; 2,8-Diaminohypoxanthine
Application:
8-Aminoguanine is a DNA-triplex stabilizing purine
CAS Number:
28128-41-8
Purity:
95%
Molecular Weight:
166.14
Molecular Formula:
C5H6N6O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
8-Aminoguanine is a guanine derivative containing an amine substitution. 8-Aminoguanine is described to confer stability to DNA triplexes when it is substituted for guanine bases in synthesized oligonucleotides.
8-Aminoguanine (CAS 28128-41-8) References
- DNA-triplex stabilizing properties of 8-aminoguanine. | Soliva, R., et al. 2000. Nucleic Acids Res. 28: 4531-9. PMID: 11071942
- Monitoring denaturation behaviour and comparative stability of DNA triple helices using oligonucleotide-gold nanoparticle conjugates. | Murphy, D., et al. 2004. Nucleic Acids Res. 32: e65. PMID: 15107480
- Evidence of strong hydrogen bonding by 8-aminoguanine. | Engelhart, AE., et al. 2009. Chem Commun (Camb). 647-9. PMID: 19322409
- 8-Aminoguanosine and 8-Aminoguanine Exert Diuretic, Natriuretic, Glucosuric, and Antihypertensive Activity. | Jackson, EK., et al. 2016. J Pharmacol Exp Ther. 359: 420-435. PMID: 27679494
- 8-Aminoguanine Induces Diuresis, Natriuresis, and Glucosuria by Inhibiting Purine Nucleoside Phosphorylase and Reduces Potassium Excretion by Inhibiting Rac1. | Jackson, EK., et al. 2018. J Am Heart Assoc. 7: e010085. PMID: 30608204
- Biochemical pathways of 8-aminoguanine production in Sprague-Dawley and Dahl salt-sensitive rats. | Jackson, EK., et al. 2022. Biochem Pharmacol. 201: 115076. PMID: 35551915
- 8-Aminoinosine and 8-Aminohypoxanthine Inhibit Purine Nucleoside Phosphorylase and Exert Diuretic and Natriuretic Activity. | Jackson, EK., et al. 2022. J Pharmacol Exp Ther. 382: 135-148. PMID: 35609923
- 8-Aminoguanine and Its Actions on Renal Excretory Function. | Jackson, EK., et al. 2023. Hypertension. 80: 981-994. PMID: 36802842
- 8-Aminopurines in the Cardiovascular and Renal Systems and Beyond. | Jackson, EK., et al. 2023. Hypertension. 80: 2265-2279. PMID: 37503660
- Oral 8-aminoguanine against age-related retinal degeneration. | Chen, Y., et al. 2024. Res Sq.. PMID: 38765984
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-Aminoguanine, 250 mg | sc-217492A | 250 mg | $240.00 | |||
8-Aminoguanine, 500 mg | sc-217492 | 500 mg | $338.00 |