Molecular structure of 8-(3-Chlorostyryl)caffeine, CAS Number: 147700-11-6
8-(3-Chlorostyryl)caffeine (CAS 147700-11-6)
See product citations (7)
Alternate Names:
CSC
Application:
8-(3-Chlorostyryl)caffeine is a selective Adenosine A2A-R and MAO-B inhibitor
CAS Number:
147700-11-6
Purity:
≥97%
Molecular Weight:
330.77
Molecular Formula:
C16H15CIN4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
8-(3-Chlorostyryl)caffeine, also known as 3-chloro-8-styrylcaffeine or 3-CSC, compound shares a structural resemblance with caffeine. While the exact mechanism of action of 8-(3-Chlorostyryl)caffeine remains partially elusive, it is believed to function as an antagonist of the A2A receptor. By doing so, it obstructs the binding of adenosine to the receptor, thereby impeding downstream signaling pathways activation. Additionally, 8-(3-Chlorostyryl)caffeine displays the ability to inhibit the enzyme cyclooxygenase-2 (COX-2).
8-(3-Chlorostyryl)caffeine (CAS 147700-11-6) References
- 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism. | Chen, JF., et al. 2002. J Biol Chem. 277: 36040-4. PMID: 12130655
- Caffeine regulates neuronal expression of the dopamine 2 receptor gene. | Stonehouse, AH., et al. 2003. Mol Pharmacol. 64: 1463-73. PMID: 14645677
- Effect of the adenosine A2A receptor antagonist 8-(3-chlorostyryl)caffeine on L-DOPA biotransformation in rat striatum. | Gołembiowska, K. and Dziubina, A. 2004. Brain Res. 998: 208-17. PMID: 14751592
- Cytokine-purine interactions in behavioral depression in rats. | Minor, TR., et al. 2003. Integr Physiol Behav Sci. 38: 189-202. PMID: 15070082
- Adenosine receptor antagonism in acute tacrolimus toxicity. | McLaughlin, GE., et al. 2006. Nephrol Dial Transplant. 21: 1961-5. PMID: 16522656
- Effect of adenosine A(2A) receptor antagonists on L-DOPA-induced hydroxyl radical formation in rat striatum. | Gołembiowska, K., et al. 2009. Neurotox Res. 15: 155-66. PMID: 19384578
- Cardioprotective effects of 2-octynyladenosine (YT-146) in ischemic/reperfused rat hearts. | Sasamori, J., et al. 2011. J Cardiovasc Pharmacol. 57: 166-73. PMID: 21052018
- Effect of adenosine A(2A) receptor antagonists and L-DOPA on hydroxyl radical, glutamate and dopamine in the striatum of 6-OHDA-treated rats. | Gołembiowska, K. and Dziubina, A. 2012. Neurotox Res. 21: 222-30. PMID: 21830163
- The role of adenosine receptors on amitriptyline-induced electrophysiological changes on rat atrium. | Kalkan, S., et al. 2013. Hum Exp Toxicol. 32: 62-9. PMID: 23111876
- An Analysis of Responses to Defibrotide in the Pulmonary Vascular Bed of the Cat. | Kaye, AD., et al. 2016. Am J Ther. 23: e757-65. PMID: 24368612
- The role of adenosine receptors and endogenous adenosine in citalopram-induced cardiovascular toxicity. | Oransay, K., et al. 2014. Indian J Pharmacol. 46: 378-85. PMID: 25097274
- 8-(3-Chlorostyryl)caffeine (CSC) is a selective A2-adenosine antagonist in vitro and in vivo. | Jacobson, KA., et al. 1993. FEBS Lett. 323: 141-4. PMID: 8495727
- Endogenous adenosine curtails lipopolysaccharide-stimulated tumour necrosis factor synthesis. | Eigler, A., et al. 1997. Scand J Immunol. 45: 132-9. PMID: 9042424
Inhibitor of:
Adenosine A2A-R, and MAO-B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-(3-Chlorostyryl)caffeine, 10 mg | sc-203786 | 10 mg | $213.00 | |||
8-(3-Chlorostyryl)caffeine, 50 mg | sc-203786A | 50 mg | $369.00 |