8,12-iso-iPF2α-VI 1,5- lactone
Molecular Weight:
336.2
Molecular Formula:
C20H32O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A racemic mixture of the lactone forms of the free acid, 8,12-iso- iPF2α-VI. Previously called IPF2α -I,2 the free acid form, iPF2α-VI, is the most abundant F2-iP regioisomer in the urine of rats treated with CCl4 to induce lipid peroxidation.3 iPF2α-VI is the only regioisomer that undergoes lactonization, and occurs slowly in vivo but can be driven chemically.4 The less polar lactone is readily separated from the free acid forms of iPF2α.4 While the level of iPF2α-VI in plasma, urine and organs is used as a biomarker for oxidative stress,5,6 some F2-iPs also evoke significant biological effects.7
8,12-iso-iPF2α-VI 1,5- lactone References
- Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL. | Van Eck, M., et al. 2007. Arterioscler Thromb Vasc Biol. 27: 2413-9. PMID: 17717299
- F2-isoprostane receptors on hepatic stellate cells. | Gardi, C., et al. 2008. Lab Invest. 88: 124-31. PMID: 18158556
- A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. | Morrow, JD., et al. 1990. Proc Natl Acad Sci U S A. 87: 9383-7. PMID: 2123555
- Identification and relative quantitation of F2-isoprostane regioisomers formed in vivo in the rat. | Waugh, RJ., et al. 1997. Free Radic Biol Med. 23: 943-54. PMID: 9378374
- IPF2alpha-I: an index of lipid peroxidation in humans. | Praticò, D., et al. 1998. Proc Natl Acad Sci U S A. 95: 3449-54. PMID: 9520386
- Total synthesis of 17,17,18,18-d4-iPF2alpha-VI and quantification of iPF2alpha-VI in human urine by gas chromatography/mass spectrometry. | Adiyaman, M., et al. 1998. Anal Biochem. 262: 45-56. PMID: 9735147
- Evidence for the formation of dinor isoprostanes E1 from alpha-linolenic acid in plants. | Parchmann, S. and Mueller, MJ. 1998. J Biol Chem. 273: 32650-5. PMID: 9830005
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8,12-iso-iPF2α-VI 1,5- lactone, 25 µg | sc-221153 | 25 µg | $123.00 | |||
8,12-iso-iPF2α-VI 1,5- lactone, 50 µg | sc-221153A | 50 µg | $237.00 |