7Z,10Z,13Z,16Z,19Z-Docosapentaenoic acid CAS: 24880-45-3
MF: C22H34O2
MW: 330.50
A fatty acid shown to inhibit platelet aggregation.

7Z,10Z,13Z,16Z,19Z-Docosapentaenoic acid (CAS 24880-45-3)

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Synonym: Docosapentaenoic acid
Application: A fatty acid shown to inhibit platelet aggregation
CAS Number: 24880-45-3
Purity: ≥98%
Molecular Weight: 330.50
Molecular Formula: C22H34O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Docosa-7Z,10Z,13Z,16Z,19Z-pentaenoic Acid (22:5, n-3), also known as DPA, is a fatty acid derived from fish oils that potently inhibits platelet aggregation. DPA has been reported to block the cyclooxygenase pathway and stimulate the lipoxygenase pathway, which results in effective platelet aggregation inhibition. Peripheral blood mononuclear cell research demonstrates that DPA diminishes cyclooxygenase-2 levels intracellularly and inhibits pro-inflammatory prostaglandin E2 production. Studies indicate that the compound plays an important role in the cubic membrane formation of mitochondria found in amoeba Chaos.


References

1. Akiba, S., et al. 2000. Biol. Pharm. Bull. 23: 1293-1297. PMID: 11085354
2. Rissanen, T., et al. 2000. Circulation. 102: 2677-2679. PMID: 11094031
3. Deng, Y., et al. 2009. FASEB J. 23: 2866-2871. PMID: 19406841
4. Nauroth, J.M., et al. 2010. Lipids. 45: 375-384. PMID: 20364438
5. Kaur, G., et al. 2011. Prog. Lipid Res. 50: 28-34. PMID: 20655949

Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in ethanol, hexane, methylene chloride, 0.1M Na2CO3 (1.7 mg/ml), water (1.7 mg/ml) at 25° C, DMSO (~100 mg/ml), and DMF (~100 mg/ml).
Storage :
Store at -20° C
Refractive Index :
n20D 1.51
IC50 :
Cytochrome P450 19A1: IC50 = 16.8 µM (human)
pK Values :
pKa: 4.76
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
JR1320000
PubChem CID :
5497182
MDL Number :
MFCD00156103
SMILES :
CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCCCC(=O)O

Download SDS (MSDS)

Certificate of Analysis

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