7BIO (CAS 916440-85-2)
See product citations (1)
QUICK LINKS
7BIO is a 3′ substituted kinase inhibitory bis-indole, which functions as a caspase independent nonapoptotic cell death inducer. Interestingly 7BIO did not inhibit the activity of CDKs and GSK-3, which is the target of many other kinase inhibitory bis-indoles. In addition, research suggests that kinase inhibitory bis-indoles, also known as indirubins, do not inhibit CDK and GSK-3 when there are substitutions on position 7 via steric hinderance. Alternate studies indicate that 7BIO can greatly reduce mitochondrial transmembrane potential. Furthermore, 7BIO causes the dilation of the Endoplasmic Reticulum and acute cytoplasmic destruction which isolated nuclei with DNA fully intact. 7BIO is also a potent inhibitor of Aurora kinase B and C.
7BIO (CAS 916440-85-2) References
- 7-Bromoindirubin-3'-oxime induces caspase-independent cell death. | Ribas, J., et al. 2006. Oncogene. 25: 6304-18. PMID: 16702956
- 3'-Substituted 7-halogenoindirubins, a new class of cell death inducing agents. | Ferandin, Y., et al. 2006. J Med Chem. 49: 4638-49. PMID: 16854069
- An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. | Myrianthopoulos, V., et al. 2007. J Med Chem. 50: 4027-37. PMID: 17665890
- 7-Bromoindirubin-3'-oxime uncovers a serine protease-mediated paradigm of necrotic cell death. | Ribas, J., et al. 2008. Biochem Pharmacol. 76: 39-52. PMID: 18485331
- Induction of discrete apoptotic pathways by bromo-substituted indirubin derivatives in invasive breast cancer cells. | Nicolaou, KA., et al. 2012. Biochem Biophys Res Commun. 425: 76-82. PMID: 22820195
- HPLC determination of serum pteridine pattern as biomarkers. | Martín Tornero, E., et al. 2014. Talanta. 128: 319-26. PMID: 25059167
- Induction of atypical cell death in thyroid carcinoma cells by the indirubin derivative 7-bromoindirubin-3'-oxime (7BIO). | Broecker-Preuss, M., et al. 2015. Cancer Cell Int. 15: 97. PMID: 26464561
- Cell Death Induction by the Indirubin Derivative 7BIO and the BH3 Mimetic Drugs ABT-737 and GX15-070 in Medullary Thyroid Carcinoma Cells. | Broecker-Preuss, M., et al. 2016. Exp Clin Endocrinol Diabetes. 124: 324-30. PMID: 26849668
- Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates Aβ Oligomer-Induced Cognitive Impairments in Mice. | Chen, L., et al. 2017. Front Mol Neurosci. 10: 393. PMID: 29234273
- Modulation of glioma-inflammation crosstalk profiles in human glioblastoma cells by indirubin-3'-(2,3 dihydroxypropyl)-oximether (E804) and 7-bromoindirubin-3'-oxime (7BIO). | Scobie, MR., et al. 2019. Chem Biol Interact. 312: 108816. PMID: 31505164
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7BIO, 10 mg | sc-221118 | 10 mg | $239.00 | |||
7BIO, 25 mg | sc-221118A | 25 mg | $720.00 |