7α-Thiomethyl Spironolactone (CAS 38753-77-4)
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7α-Thiomethyl Spironolactone is an analog of spironolactone and serves as useful in biochemical research, particularly in the study of mineralocorticoid receptor antagonism. This sulfur-containing derivative is utilized in the investigation of aldosterone′s role in electrolyte balance and the regulation of water retention. Researchers employ this compound to examine the effects of blocking aldosterone receptors on sodium and potassium homeostasis. Additionally, 7α-Thiomethyl Spironolactone′s unique structure allows for the exploration of structure-activity relationships (SAR) in the development of new compounds with potential receptor binding properties. In endocrinology, this compound aids in elucidating the complex mechanisms underlying hormonal regulation and the potential for targeted modulation of receptor activity. Moreover, in biochemistry, it is used to study the enzyme-inhibiting properties of spironolactone derivatives and their interactions with various biosynthetic pathways.
7α-Thiomethyl Spironolactone (CAS 38753-77-4) References
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- Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs. | Sanomachi, T., et al. 2019. Cancers (Basel). 11: PMID: 31614999
- Mineralocorticoid receptor antagonist treatment of established pulmonary arterial hypertension improves interventricular dependence in the SU5416-hypoxia rat model. | Lu, M., et al. 2022. Am J Physiol Lung Cell Mol Physiol. 322: L315-L332. PMID: 35043674
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7α-Thiomethyl Spironolactone, 1 mg | sc-207187 | 1 mg | $312.00 | |||
7α-Thiomethyl Spironolactone, 2 mg | sc-207187A | 2 mg | $573.00 | |||
7α-Thiomethyl Spironolactone, 5 mg | sc-207187B | 5 mg | $1301.00 | |||
7α-Thiomethyl Spironolactone, 10 mg | sc-207187C | 10 mg | $2091.00 |