Molecular structure of 7α-Hydroxy-4-cholesten-3-one, CAS Number: 3862-25-7
7α-Hydroxy-4-cholesten-3-one (CAS 3862-25-7)
See product citations (5)
Alternate Names:
(7α)-7-Hydroxycholest-4-en-3-one; 7α-Hydroxycholest-4-en-3-one
Application:
7α-Hydroxy-4-cholesten-3-one is a metabolite of cholesterol
CAS Number:
3862-25-7
Molecular Weight:
400.64
Molecular Formula:
C27H44O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
7α-Hydroxy-4-cholesten-3-one (7alpha-HC) is a naturally occurring oxysterol and a metabolic intermediate within the cholesterol biosynthesis pathway. This compound not only acts as a potent agonist of the Liver X Receptor (LXR) but is a key regulator of cholesterol metabolism. By exerting its agonistic effects on the LXR, 7alpha-HC initiates events that lead to the upregulation of genes responsible for cholesterol efflux and the concomitant downregulation of genes involved in cholesterol uptake and biosynthesis. This response results in a reduction in cholesterol levels. It exhibits anti-inflammatory and antioxidant effects.
7α-Hydroxy-4-cholesten-3-one (CAS 3862-25-7) References
- Significance of plasma 7alpha-hydroxy-4-cholesten-3-one and 27-hydroxycholesterol concentrations as markers for hepatic bile acid synthesis in cholesterol-fed rabbits. | Honda, A., et al. 2004. Metabolism. 53: 42-8. PMID: 14681840
- Coffee oil consumption increases plasma levels of 7alpha-hydroxy-4-cholesten-3-one in humans. | Boekschoten, MV., et al. 2005. J Nutr. 135: 785-9. PMID: 15795435
- Highly sensitive quantification of 7alpha-hydroxy-4-cholesten-3-one in human serum by LC-ESI-MS/MS. | Honda, A., et al. 2007. J Lipid Res. 48: 458-64. PMID: 17093295
- Novel LC-MS/MS method for assay of 7alpha-hydroxy-4-cholesten-3-one in human plasma. Evidence for a significant extrahepatic metabolism. | Lövgren-Sandblom, A., et al. 2007. J Chromatogr B Analyt Technol Biomed Life Sci. 856: 15-9. PMID: 17561450
- Correlation between plasma levels of 7alpha-hydroxy-4-cholesten-3-one and cholesterol 7alpha-hydroxylation rates in vivo in hyperlipidemic patients. | Bertolotti, M., et al. 2008. Steroids. 73: 1197-202. PMID: 18582481
- ESI-MS/MS quantification of 7alpha-hydroxy-4-cholesten-3-one facilitates rapid, convenient diagnostic testing for cerebrotendinous xanthomatosis. | DeBarber, AE., et al. 2010. Clin Chim Acta. 411: 43-8. PMID: 19808031
- An efficient synthesis of 7α,12α-dihydroxy-4-cholesten-3-one and its biological precursor 7α-hydroxy-4-cholesten-3-one: Key intermediates in bile acid biosynthesis. | Ogawa, S., et al. 2013. Steroids. 78: 927-37. PMID: 23707572
- Bile acid malabsorption assessed by 7 alpha-hydroxy-4-cholesten-3-one in pediatric inflammatory bowel disease: correlation to clinical and laboratory findings. | Gothe, F., et al. 2014. J Crohns Colitis. 8: 1072-8. PMID: 24666974
- Measurement of serum 7α-hydroxy-4-cholesten-3-one as a marker of bile acid malabsorption in dogs with chronic diarrhoea: a pilot study. | Kent, AC., et al. 2016. Vet Rec Open. 3: e000163. PMID: 27110372
- Comparison of simple extraction procedures in liquid chromatography-mass spectrometry based determination of serum 7α-hydroxy-4-cholesten-3-one, a surrogate marker of bile acid synthesis. | LeníĿek, M., et al. 2016. J Chromatogr B Analyt Technol Biomed Life Sci. 1033-1034: 317-320. PMID: 27598558
- LC-MS/MS quantification of 7α-hydroxy-4-cholesten-3-one (C4) in rat and monkey plasma. | Kang, L., et al. 2017. J Chromatogr B Analyt Technol Biomed Life Sci. 1064: 49-55. PMID: 28915417
- A dysregulated bile acid-gut microbiota axis contributes to obesity susceptibility. | Wei, M., et al. 2020. EBioMedicine. 55: 102766. PMID: 32408110
- Pegbelfermin selectively reduces secondary bile acid concentrations in patients with non-alcoholic steatohepatitis. | Luo, Y., et al. 2022. JHEP Rep. 4: 100392. PMID: 34977519
- Serum concentrations of 7alpha-hydroxy-4-cholesten-3-one reflect bile acid synthesis in humans. | Sauter, G., et al. 1996. Hepatology. 24: 123-6. PMID: 8707250
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7α-Hydroxy-4-cholesten-3-one, 1 mg | sc-210660 | 1 mg | $557.00 | |||
7α-Hydroxy-4-cholesten-3-one, 5 mg | sc-210660A | 5 mg | $2092.00 | |||
7α-Hydroxy-4-cholesten-3-one, 10 mg | sc-210660B | 10 mg | $4086.00 | |||
7α-Hydroxy-4-cholesten-3-one, 25 mg | sc-210660C | 25 mg | $6636.00 |