Date published: 2026-4-12

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7α,12α-Dihydroxycholest-4-en-3-one (CAS 1254-03-1)

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Alternate Names:
(7α,12α)-7,12-Dihydroxycholest-4-en-3-one; Cholest-4-ene-7α,12α-diol-3-one
Application:
7α,12α-Dihydroxycholest-4-en-3-one is a metabolite of Hydroxysitosterol and Hydroxycholesterol
CAS Number:
1254-03-1
Molecular Weight:
416.64
Molecular Formula:
C27H44O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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7α,12α-Dihydroxycholest-4-en-3-one is a metabolite of Hydroxysitosterol and Hydroxycholesterol. 7α,12α-Dihydroxycholest-4-en-3-one is a naturally occurring steroid hormone that is primarily synthesized in the adrenal glands. It displays neuroprotective effects. Through various mechanisms, such as inhibiting the production of pro-inflammatory cytokines and reducing oxidative stress, it contributes to the regulation of inflammatory responses.


7α,12α-Dihydroxycholest-4-en-3-one (CAS 1254-03-1) References

  1. Analytical strategies for characterization of oxysterol lipidomes: liver X receptor ligands in plasma.  |  Griffiths, WJ., et al. 2013. Free Radic Biol Med. 59: 69-84. PMID: 22846477
  2. In-Depth Dissection of the P133R Mutation in Steroid 5β-Reductase (AKR1D1): A Molecular Basis of Bile Acid Deficiency.  |  Chen, M., et al. 2015. Biochemistry. 54: 6343-51. PMID: 26418565
  3. Defective cholesterol metabolism in amyotrophic lateral sclerosis.  |  Abdel-Khalik, J., et al. 2017. J Lipid Res. 58: 267-278. PMID: 27811233
  4. Identification of 7α,24-dihydroxy-3-oxocholest-4-en-26-oic and 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acids in human cerebrospinal fluid and plasma.  |  Abdel-Khalik, J., et al. 2018. Biochimie. 153: 86-98. PMID: 29960034
  5. Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma.  |  Griffiths, WJ., et al. 2019. Biochim Biophys Acta Mol Cell Biol Lipids. 1864: 191-211. PMID: 30471425
  6. Elevated oxysterol levels in human and mouse livers reflect nonalcoholic steatohepatitis.  |  Raselli, T., et al. 2019. J Lipid Res. 60: 1270-1283. PMID: 31113816
  7. Metabolic profiling in serum, cerebrospinal fluid, and brain of patients with cerebrotendinous xanthomatosis.  |  Höflinger, P., et al. 2021. J Lipid Res. 62: 100078. PMID: 33891937
  8. A synthesis of a rationally designed inhibitor of cytochrome P450 8B1, a therapeutic target to treat obesity.  |  Chung, E., et al. 2022. Steroids. 178: 108952. PMID: 34968450
  9. The structure and characterization of human cytochrome P450 8B1 supports future drug design for nonalcoholic fatty liver disease and diabetes.  |  Liu, J., et al. 2022. J Biol Chem. 298: 102344. PMID: 35944583
  10. On the conversion of cholesterol to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one. Bile acids and steroids 168.  |  Danielsson, H. and Einarsson, K. 1966. J Biol Chem. 241: 1449-54. PMID: 4380319
  11. Formation of bile acids in man: conversion of cholesterol into 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol in liver homogenates.  |  Björkheim, I., et al. 1968. J Clin Invest. 47: 1573-82. PMID: 4385432
  12. Stero-bile acids and bile alcohols. CV. Conversion of 7alpha, 12-alpha-dihydroxycholest-4-en-3-one to 5-alpha-cyprinol by carp liver.  |  Hoshita, T. 1969. J Biochem. 66: 313-9. PMID: 4390686
  13. Conversion of 7-alpha,12-alpha-dihydroxycholest-4-en-3-one to 5-alpha-cholestane-3-alpha, 7-alpha,12-alpha-triol by iguana liver microsomes.  |  Hoshita, T., et al. 1968. J Lipid Res. 9: 237-43. PMID: 5640503
  14. Sex differences in gallbladder bile acid composition and hepatic steroid 12 alpha-hydroxylase activity in hamsters.  |  Kuroki, S., et al. 1983. J Lipid Res. 24: 1543-9. PMID: 6421973

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

7α,12α-Dihydroxycholest-4-en-3-one, 0.5 mg

sc-207188
0.5 mg
$449.00

7α,12α-Dihydroxycholest-4-en-3-one, 1 mg

sc-207188A
1 mg
$709.00