Date published: 2025-12-11

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7-Oxostaurosporine (CAS 141196-69-2)

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Application:
7-Oxostaurosporine is an oxidized and highly fluorescent analogue of Antibiotics UCN-01 and UCN-02
CAS Number:
141196-69-2
Purity:
>98%
Molecular Weight:
480.5
Molecular Formula:
C28H24N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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7-Oxostaurosporine, registered under CAS number 141196-69-2, is a synthetic derivative of the natural product staurosporine, known for its potent kinase inhibitory activity. This compound is characterized by a modification at the 7-position of the staurosporine molecule, which alters its interaction with various kinases. 7-Oxostaurosporine acts primarily by inhibiting protein kinases, crucial enzymes that phosphorylate proteins and thereby regulate numerous cellular processes including cell cycle, growth, and apoptosis. By blocking the activity of these kinases, 7-Oxostaurosporine interferes with signal transduction pathways inside cells, leading to an alteration in cellular functions such as division and survival. In research, 7-Oxostaurosporine is employed to study kinase-dependent pathways, offering insights into the molecular mechanisms that govern cell behavior. It is particularly useful for dissecting the roles of specific kinases in cellular processes and for identifying potential regulatory targets within those pathways. Additionally, this compound helps in exploring the broader implications of kinase inhibition on cellular physiology and pathology. Through these scientific applications, 7-Oxostaurosporine serves as a valuable tool in the fields of cellular biology and biochemistry, enhancing our understanding of the complex network of signaling pathways that influence cell function and fate.


7-Oxostaurosporine (CAS 141196-69-2) References

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  2. A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). II. Fermentation, isolation, physico-chemical properties and structure.  |  Koshino, H., et al. 1992. J Antibiot (Tokyo). 45: 195-8. PMID: 1556010
  3. Structure elucidation and anticancer activity of 7-oxostaurosporine derivatives from the Brazilian endemic tunicate Eudistoma vannamei.  |  Jimenez, PC., et al. 2012. Mar Drugs. 10: 1092-1102. PMID: 22822359
  4. Staurosporine: A new tool for studying phosphatidylserine trafficking.  |  Cho, KJ., et al. 2013. Commun Integr Biol. 6: e24746. PMID: 23986809
  5. Antiamoebic Activities of Indolocarbazole Metabolites Isolated from Streptomyces sanyensis Cultures.  |  Cartuche, L., et al. 2019. Mar Drugs. 17: PMID: 31627366
  6. Antikinetoplastid Activity of Indolocarbazoles from Streptomyces sanyensis.  |  Cartuche, L., et al. 2020. Biomolecules. 10: PMID: 32344693
  7. Evaluation of Indolocarbazoles from Streptomyces sanyensis as a Novel Source of Therapeutic Agents against the Brain-Eating Amoeba Naegleria fowleri.  |  Rizo-Liendo, A., et al. 2020. Microorganisms. 8: PMID: 32466301
  8. Identification, Structure-Activity Relationships of Marine-Derived Indolocarbazoles, and a Dual PKCθ/δ Inhibitor with Potent Antipancreatic Cancer Efficacy.  |  Wang, J., et al. 2020. J Med Chem. 63: 12978-12991. PMID: 33100009
  9. Sequential Metal Catalysis towards 7-Oxostaurosporine and Its Non-Natural Septanose Analogue.  |  Seo, K., et al. 2022. Angew Chem Int Ed Engl. 61: e202112524. PMID: 34786807
  10. Antitumour effects and pharmacokinetics of combination of vinblastine with a staurosporine derivative, NA-382, in P388/ADR-bearing mice.  |  Miyamoto, K., et al. 1995. J Pharm Pharmacol. 47: 524-9. PMID: 7674138
  11. Effect of staurosporine derivatives on protein kinase activity and vinblastine accumulation in mouse leukaemia P388/ADR cells.  |  Miyamoto, K., et al. 1993. J Pharm Pharmacol. 45: 43-7. PMID: 8094445
  12. Screening of cell cycle inhibitors from microbial metabolites by a bioassay using a mouse cdc2 mutant cell line, tsFT210.  |  Osada, H., et al. 1997. Bioorg Med Chem. 5: 193-203. PMID: 9043671
  13. Leukocyte function-associated antigen 1-dependent adhesion of rat hepatoma AH66F cells and inhibition by protein kinase C inhibitors.  |  Nomura, M., et al. 1997. Biochem Pharmacol. 53: 1333-7. PMID: 9214694

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

7-Oxostaurosporine, 1 mg

sc-202027
1 mg
$369.00