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Molecular structure of 7-nitro-10-octyl-3-phenyl-pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione, CAS Number: 137346-42-0
7-nitro-10-octyl-3-phenyl-pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (CAS 137346-42-0)
Application:
7-nitro-10-octyl-3-phenyl-pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione is an antagonist of the interaction between survivin and the apoptosis-promoting protein Smac/Diablo, exhibiting an IC50 value of 2.2 μM.
CAS Number:
137346-42-0
Molecular Weight:
446.5
Molecular Formula:
C25H26N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Survivin is a cellular protein implicated in cell survival by interacting with and inhibiting the apoptotic function of several proteins including Smac/Diablo, caspase-3, and caspase-7. Survivin also plays a role in the regulation of the cell cycle as part of a protein complex that includes INCENP, Aurora B kinase, and Borealin. An antagonist of the interaction between survivin and the apoptosis-promoting protein Smac/Diablo, exhibiting an IC50 value of 2.2 µM. It inhibits the interaction of survivin with INCENP less effectively with an IC50 value of 20 µM. Cell-permeable and sensitizes cells to the induction of apoptosis by doxorubicin.
7-nitro-10-octyl-3-phenyl-pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (CAS 137346-42-0) References
- An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7. | Shin, S., et al. 2001. Biochemistry. 40: 1117-23. PMID: 11170436
- Survivin: a new target for anti-cancer therapy. | Ryan, BM., et al. 2009. Cancer Treat Rev. 35: 553-62. PMID: 19559538
- Identification of a small-molecule inhibitor of the interaction between Survivin and Smac/DIABLO. | Oikawa, T., et al. 2010. Biochem Biophys Res Commun. 393: 253-8. PMID: 20117083
Inhibitor of:
Apoptosis.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7-nitro-10-octyl-3-phenyl-pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione, 1 mg | sc-352980 | 1 mg | $75.00 | |||
7-nitro-10-octyl-3-phenyl-pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione, 5 mg | sc-352980A | 5 mg | $331.00 |