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7-Methylguanosine 5′-triphosphate sodium salt (CAS 104809-18-9)

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CAS Number:
104809-18-9
Purity:
≥85%
Molecular Weight:
537.21 (free acid basis)
Molecular Formula:
C11H18N5O14P3•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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7-Methylguanosine 5′-triphosphate sodium salt, often abbreviated as 7mGTP or m7GTP, is a modified nucleotide derivative. It is a nucleotide composed of three components: a guanine base, a ribose sugar, and three phosphate groups. The sodium salt form enhances its stability and solubility. 7-Methylguanosine 5′-triphosphate (m7GTP) is utilized to investigate eukaryotic cellular mRNA caps, their structures, and mechanisms, particularly their role in protein synthesis. It is also employed in creating affinity media for capturing and purifying molecules like eukaryotic initiation factor eIF4E.


7-Methylguanosine 5′-triphosphate sodium salt (CAS 104809-18-9) References

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  2. The human Ago2 MC region does not contain an eIF4E-like mRNA cap binding motif.  |  Kinch, LN. and Grishin, NV. 2009. Biol Direct. 4: 2. PMID: 19159466
  3. Translation of vitellogenin mRNA in the presence of 7-methylguanosine 5'-triphosphate. Cap analogs compete with mRNAs on the basis of affinity for initiation-complex formation.  |  Willems, M., et al. 1979. Eur J Biochem. 93: 469-79. PMID: 217682
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  6. Nucleotide resolution profiling of m7G tRNA modification by TRAC-Seq.  |  Lin, S., et al. 2019. Nat Protoc. 14: 3220-3242. PMID: 31619810
  7. Aberrant translation regulated by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives head and neck squamous cell carcinoma progression.  |  Chen, J., et al. 2022. Cancer Commun (Lond). 42: 223-244. PMID: 35179319
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  13. A fluorescence spectroscopic study on the binding of mRNA 5'-cap-analogs to human translation initiation factor eIF4E: a critical evaluation of the sources of error.  |  Wieczorek, Z., et al. 1998. J Photochem Photobiol B. 43: 158-63. PMID: 9679316

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

7-Methylguanosine 5′-triphosphate sodium salt, 5 mg

sc-214409
5 mg
$198.00

7-Methylguanosine 5′-triphosphate sodium salt, 10 mg

sc-214409A
10 mg
$333.00

7-Methylguanosine 5′-triphosphate sodium salt, 25 mg

sc-214409B
25 mg
$656.00