7-Methylguanine (CAS 578-76-7)
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7-Methylguanine (7MG) is a compound that possesses a diverse array of applications in scientific research. As a modified nucleoside derived from guanine, it holds significant importance as a fundamental component of both DNA and RNA. Its extensive utilization spans various research areas, encompassing the examination of gene expression and regulation, protein-DNA interactions, and enzyme mechanisms. 7-Methylguanine acts as an inhibitor of DNA polymerase, the enzyme responsible for DNA replication. By binding to DNA polymerase, 7-Methylguanine effectively impedes its activity, thus thwarting the process of DNA replication. Additionally, 7MG is recognized for its ability to bind to other proteins involved in DNA repair, such as DNA repair enzymes and transcription factors.
7-Methylguanine (CAS 578-76-7) References
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- 7-Methylguanine: protonation, formation of linkage isomers with trans-(NH3)2Pt(II), and base pairing properties. | Kozma, Á., et al. 2012. Dalton Trans. 41: 6094-103. PMID: 22354137
- Depurination from DNA of 7-methylguanine, 7-(2-aminoethyl)-guanine and ring-opened 7-methylguanines. | Hemminki, K., et al. 1989. Chem Biol Interact. 70: 289-303. PMID: 2743474
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- Molecular Mechanisms of PARP-1 Inhibitor 7-Methylguanine. | Nilov, D., et al. 2020. Int J Mol Sci. 21: PMID: 32245127
- Modeling the Structure of Human tRNA-Guanine Transglycosylase in Complex with 7-Methylguanine and Revealing the Factors that Determine the Enzyme Interaction with Inhibitors. | Pushkarev, SV., et al. 2022. Biochemistry (Mosc). 87: 443-449. PMID: 35790378
- Toxicological Properties of 7-Methylguanine, and Preliminary Data on its Anticancer Activity. | Kirsanov, K., et al. 2022. Front Pharmacol. 13: 842316. PMID: 35873588
- Inhibitory Effects of 7-Methylguanine and Its Metabolite 8-Hydroxy-7-Methylguanine on Human Poly(ADP-Ribose) Polymerase 1. | Kurgina, TA., et al. 2022. Biochemistry (Mosc). 87: 823-831. PMID: 36171646
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7-Methylguanine, 250 mg | sc-233692 | 250 mg | $131.00 | |||
7-Methylguanine, 500 mg | sc-233692A | 500 mg | $212.00 | |||
7-Methylguanine, 1 g | sc-233692B | 1 g | $359.00 |