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Molecular structure of 7-Methylbenz[a]anthracene, CAS Number: 2541-69-7
7-Methylbenz[a]anthracene (CAS 2541-69-7)
Alternate Names:
7-Monomethylbenz[a]anthracene; 3,4-Benz-9-methylanthracene
CAS Number:
2541-69-7
Molecular Weight:
242.31
Molecular Formula:
C19H14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
7-Methylbenz[a]anthracene is a polycyclic aromatic hydrocarbon that functions as a potent carcinogen in experimental applications. It acts by intercalating into DNA, causing mutations and disrupting normal cellular processes. 7-Methylbenz[a]anthracene is known to induce tumors in various animal models, making it useful for studying the mechanisms of carcinogenesis and tumor development. Its mechanism of action involves the activation of specific metabolic pathways that ultimately result in the formation of reactive intermediates capable of damaging DNA and promoting tumor growth.
7-Methylbenz[a]anthracene (CAS 2541-69-7) References
- Comparison of the products of the reaction of 7-methylbenz(a)anthracene 5,6-oxide and RNA, with those formed in 7-methylbenz(a)anthracene-treated cells. | Baird, WM., et al. 1976. Cancer Res. 36: 2306-11. PMID: 1277134
- Strong influence of the exposure medium on mutagenicity in the Ames test: 7-methylbenz[a]anthracene-5,6-oxide. | Glatt, H., et al. 1991. Mutagenesis. 6: 537-40. PMID: 1800902
- Bioalkylation of benz[a]anthracene, 7-methylbenz[a]anthracene, and 12-methylbenz[a]anthracene in rat lung cytosol preparations. | Myers, SR. and Flesher, JW. 1991. Biochem Pharmacol. 41: 1683-9. PMID: 2043157
- Metabolic activation of 7-ethyl- and 7-methylbenz[a]anthracene in mouse skin. | McKay, S., et al. 1988. Carcinogenesis. 9: 141-5. PMID: 3335039
- Oxidative metabolism of 7-methylbenz[a]anthracene, 12-methylbenz[a]anthracene and 7,12-dimethylbenz[a]anthracene by rat liver cytosol. | Flesher, JW. and Myers, SR. 1985. Cancer Lett. 26: 83-8. PMID: 3918789
- The activity of 7-methylbenz(a)anthracene metabolites in an in vitro-in vivo carcinogenicity test using mouse lung tissue. | Flaks, A. and Sims, P. 1977. Cancer Lett. 3: 163-7. PMID: 409482
- The metabolism of 7- and 12-methylbenz[a]anthracene and their derivatives. | Sims, P. 1967. Biochem J. 105: 591-8. PMID: 5584001
- Stereoselective metabolism of 7-methylbenz[a]anthracene: absolute configuration of five dihydrodiol metabolites and the effect of dihydrodiol conformation on circular dichroism spectra. | Yang, SK. and Fu, PP. 1984. Chem Biol Interact. 49: 71-88. PMID: 6722941
- The preparation of dihydrodiols from 7-methylbenz[a]-anthracene. | Tierney, B., et al. 1978. Chem Biol Interact. 21: 289-98. PMID: 679402
- Metabolism of 7-methylbenz[a]anthracene and 7-hydroxymethylbenz[a]anthracene by Cunninghamella elegans. | Cerniglia, CE., et al. 1982. Appl Environ Microbiol. 44: 682-9. PMID: 7138006
- In vitro malignant transformation of mouse fibroblasts by non-K-region dihydrodiols derived from 7-methylbenz(a)anthracene, 7,12-dimethylbenz(a)anthracene, and benzo(a)pyrene. | Marquardt, H., et al. 1976. Cancer Res. 36: 2059-64. PMID: 817799
- The metabolic activation of 7-methylbenz(a)anthracene: the induction of malignant transformation and mutation in mammalian cells by non-K-region dihydrodiols. | Marquardt, H., et al. 1977. Int J Cancer. 19: 828-33. PMID: 873646
- The effect of fluoro substituents on reactivity of 7-methylbenz[a]anthracene diol epoxides. | Baer-Dubowska, W., et al. 1996. Chem Res Toxicol. 9: 722-8. PMID: 8831816
- The metabolic activation of 7-methylbenz(a)anthracene in mouse skin. | Tierney, B., et al. 1977. Chem Biol Interact. 18: 179-93. PMID: 890846
- Analysis of 7-methylbenz[a]anthracene-DNA adducts formed in SENCAR mouse epidermis by 32P-postlabeling. | Baer-Dubowska, W., et al. 1997. Carcinogenesis. 18: 523-9. PMID: 9067552
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7-Methylbenz[a]anthracene, 10 mg | sc-483421 | 10 mg | $354.00 |