Date published: 2025-10-14

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7-Methoxycoumarin (CAS 531-59-9)

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Alternate Names:
Herniarin; Methyl umbelliferyl ether
Application:
7-Methoxycoumarin is a compound biosynthesized in lavender that exhibits antimicrobial activity
CAS Number:
531-59-9
Purity:
≥97%
Molecular Weight:
176.17
Molecular Formula:
C10H8O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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7-Methoxycoumarin is extensively used in organic chemistry and biochemistry research as a fluorophore due to its fluorescent properties. It serves as a building block in the synthesis of various fluorescent probes and reagents that are utilized in the detection, quantification, and tracking of biological molecules. In the area of enzyme kinetics, 7-Methoxycoumarin derivatives are employed to investigate the activity of esterases and proteases, where the enzymatic cleavage results in fluorescence changes that can be easily monitored. The compound is also involved in the study of photochemical reactions, providing insights into the behavior of coumarin compounds when exposed to light. Furthermore, 7-Methoxycoumarin is used in the development of optical sensors, where its light-emitting properties are harnessed to create sensitive and selective detection systems for various analytes.


7-Methoxycoumarin (CAS 531-59-9) References

  1. Simultaneous determination of 6-methylcoumarin and 7-methoxycoumarin in cosmetics using three-dimensional excitation-emission matrix fluorescence coupled with second-order calibration methods.  |  Nie, JF., et al. 2008. Talanta. 75: 1260-9. PMID: 18585211
  2. Dealkylation of 7-methoxycoumarin as assay for measuring constitutive and phenobarbital-inducible cytochrome P450s.  |  Reen, RK., et al. 1991. Anal Biochem. 194: 243-9. PMID: 1862930
  3. Analysis of fluorescence quenching of coumarin derivatives by 4-hydroxy-TEMPO in aqueous solution.  |  Żamojć, K., et al. 2014. J Fluoresc. 24: 713-8. PMID: 24337873
  4. Estrogen-like and tissue-selective effects of 7-methoxycoumarin from Ficus umbellata (Moraceae): an in vitro and in vivo study.  |  Zingue, S., et al. 2017. BMC Complement Altern Med. 17: 383. PMID: 28768532
  5. Influence of medium composition on 7-alkoxycoumarin O-dealkylase activities of rat hepatocytes in primary maintenance culture.  |  Warren, M. and Fry, JR. 1988. Xenobiotica. 18: 973-81. PMID: 2973183
  6. Effects of Ficus umbellata (Moraceae) Aqueous Extract and 7-Methoxycoumarin on Scopolamine-Induced Spatial Memory Impairment in Ovariectomized Wistar Rats.  |  Zingue, S., et al. 2018. Behav Neurol. 2018: 5751864. PMID: 30363978
  7. Fluorescence quenching by photoinduced electron transfer between 7-methoxycoumarin and guanine base facilitated by hydrogen bonds: an in silico study.  |  Thongyod, W., et al. 2019. Phys Chem Chem Phys. 21: 16258-16269. PMID: 31304496
  8. Identification of two bitter components in Zanthoxylum bungeanum Maxim. and exploration of their bitter taste mechanism through receptor hTAS2R14.  |  Ke, J., et al. 2021. Food Chem. 338: 127816. PMID: 32818866
  9. A 7-methoxybicoumarin derivative selectively inhibits BRD4 BD2 for anti-melanoma therapy.  |  Yang, GJ., et al. 2020. Int J Biol Macromol. 164: 3204-3220. PMID: 32860796
  10. Monosubstituted Coumarins Inhibit Epinephrine-induced Platelet Aggregation.  |  Jiménez-Orozco, FA., et al. 2022. Cardiovasc Hematol Agents Med Chem. 20: 43-51. PMID: 33906594
  11. Preliminary Studies on the Antibacterial Mechanism of a New Plant-Derived Compound, 7-Methoxycoumarin, Against Ralstonia solanacearum.  |  Han, S., et al. 2021. Front Microbiol. 12: 697911. PMID: 34421853
  12. The ethanolic extract of Artemisia anomala exerts anti-inflammatory effects via inhibition of NLRP3 inflammasome.  |  Hong, F., et al. 2022. Phytomedicine. 102: 154163. PMID: 35597027
  13. Allelochemicals from the Rhizosphere Soil of Potato (Solanum tuberosum L.) and Their Interactions with the Soilborne Pathogens.  |  Xin, A., et al. 2022. Plants (Basel). 11: PMID: 35893638

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

7-Methoxycoumarin, 5 g

sc-217460
5 g
$48.00

7-Methoxycoumarin, 25 g

sc-217460A
25 g
$180.00