Date published: 2025-10-17

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7-Ketocholesterol-d7 (CAS 127684-08-6)

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Application:
7-Ketocholesterol-d7 is A labeled metabolite of Cholesterol
CAS Number:
127684-08-6
Molecular Weight:
407.68
Molecular Formula:
C27H37D7O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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7-Ketocholesterol-d7 is a deuterated compound used extensively in the study of lipid oxidation processes. It serves as an internal standard in mass spectrometry-based lipidomic studies due to its isotopic labeling, which allows for precise quantification of 7-ketocholesterol in biological samples. Research on this compound aids in understanding the role of oxidized cholesterol derivatives in cell membrane structure and function. It is also employed in studies investigating the mechanisms of age-related diseases, as 7-ketocholesterol accumulation has been associated with cellular damage and the progression of certain conditions. Additionally, 7-Ketocholesterol-d7 is utilized in the exploration of atherosclerosis development, where it helps in elucidating the contribution of cholesterol oxidation products to plaque formation within arterial walls.


7-Ketocholesterol-d7 (CAS 127684-08-6) References

  1. Clinical significance of serum 7-ketocholesterol concentrations in the progression of coronary atherosclerosis.  |  Hitsumoto, T., et al. 2009. J Atheroscler Thromb. 16: 363-70. PMID: 19672027
  2. Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors.  |  Matysik, S., et al. 2012. Clin Chem. 58: 1557-64. PMID: 22997279
  3. Determination of 7-ketocholesterol in plasma by LC-MS for rapid diagnosis of acid SMase-deficient Niemann-Pick disease.  |  Lin, N., et al. 2014. J Lipid Res. 55: 338-43. PMID: 24190732
  4. Potential of gas chromatography-atmospheric pressure chemical ionization-time-of-flight mass spectrometry for the determination of sterols in human plasma.  |  Matysik, S., et al. 2014. Biochem Biophys Res Commun. 446: 751-5. PMID: 24463103
  5. High density lipoprotein efficiently accepts surface but not internal oxidised lipids from oxidised low density lipoprotein.  |  Rasmiena, AA., et al. 2016. Biochim Biophys Acta. 1861: 69-77. PMID: 26569052
  6. Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry.  |  Pataj, Z., et al. 2016. J Chromatogr A. 1439: 82-88. PMID: 26607314
  7. High level of oxysterols in neonatal cholestasis: a pitfall in analysis of biochemical markers for Niemann-Pick type C disease.  |  Polo, G., et al. 2016. Clin Chem Lab Med. 54: 1221-9. PMID: 26650075
  8. Plasma 7-ketocholesterol levels and the risk of incident cardiovascular events.  |  Wang, M., et al. 2017. Heart. 103: 1788-1794. PMID: 28490621
  9. Rapid screening for lipid storage disorders using biochemical markers. Expert center data and review of the literature.  |  Voorink-Moret, M., et al. 2018. Mol Genet Metab. 123: 76-84. PMID: 29290526
  10. Simvastatin reduces circulating oxysterol levels in men with hypercholesterolaemia.  |  Dias, IHK., et al. 2018. Redox Biol. 16: 139-145. PMID: 29501047
  11. A comprehensive method to determine sterol species in human faeces by GC-triple quadrupole MS.  |  Kunz, S. and Matysik, S. 2019. J Steroid Biochem Mol Biol. 190: 99-103. PMID: 30923016
  12. Plasma advanced glycation end products and soluble receptor for advanced glycation end products as indicators of sterol content in human carotid atherosclerotic plaques.  |  Pinto, RS., et al. 2022. Diab Vasc Dis Res. 19: 14791641221085269. PMID: 35343275
  13. Identification and quantification of ionising radiation-induced oxysterol formation in membranes of lens fibre cells  |  A Uwineza, I Cummins, M Jarrin, AA Kalligeraki… - Advances in Redox …, 2023 - Elsevier. April 2023,. Advances in Redox Research. Volume 7,: 100057.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

7-Ketocholesterol-d7, 1 mg

sc-207177
1 mg
$279.00