Molecular structure of 7-Hydroxycoumarin glucuronide sodium salt, CAS Number: 66695-14-5 (non-salt)
7-Hydroxycoumarin glucuronide sodium salt (CAS 66695-14-5 (non-salt))
Alternate Names:
7-Hydroxycoumarin glucuronide sodium salt is known as a 7-hydroxy coumarin phase II metabolite.
Application:
7-Hydroxycoumarin glucuronide sodium salt is a 7-hydroxycoumarin phase II metabolite that can be used as a standard for the analysis of 7-hydroxy coumarin metabolism.
CAS Number:
66695-14-5 (non-salt)
Molecular Weight:
360.25
Molecular Formula:
C15H13NaO9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
7-Hydroxycoumarin glucuronide sodium salt is a labelled metabolite of Coumarin and 7-hydroxycoumarin phase II that can be used as a standard for the analysis of 7-hydroxy coumarin metabolism. 7-Hydroxycoumarin glucuronide sodium salt was one of the eventually formed metabolites following a 1 hour incubation experiment with individual probe substrates, such as Chlorzoxazone and 7-hydroxycoumarin. The measured concentration of formed 7-Hydroxycoumarin glucuronide sodium salt can be indicative of the presence of UGT enzyme after exposure of HepaRG to the original probe substrate. 7-Hydroxycoumarin glucuronide sodium salt was undetectable in an LC-MS/MS analysis test in AR-CALUX.
7-Hydroxycoumarin glucuronide sodium salt (CAS 66695-14-5 (non-salt)) References
- Cytochrome P450 maintenance and diazepam metabolism in cultured rat hepatocytes. | Blankson, EA., et al. 1991. Biochem Pharmacol. 42: 1241-5. PMID: 1888333
- Effect of chromium and cobalt ions on phase I and phase II enzymatic activities in vitro in freshly isolated rat hepatocytes. | Afolaranmi, GA., et al. 2011. Toxicol In Vitro. 25: 125-30. PMID: 20946949
- Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea pig, cynomolgus monkey and human precision-cut liver slices. | Steensma, A., et al. 1994. Xenobiotica. 24: 893-907. PMID: 7810171
- Xenobiotic metabolism in rat, dog, and human precision-cut liver slices, freshly isolated hepatocytes, and vitrified precision-cut liver slices. | Ekins, S., et al. 1996. Drug Metab Dispos. 24: 990-5. PMID: 8886609
- Dynamic Organ Culture is Superior to Multiwell Plate Culture for Maintaining Precision-Cut Tissue Slices: Optimization of Tissue Slice Culture, Part 1 | Robyn L. Fisher, et al. 1995. Toxicology Methods. 5: 99-113.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7-Hydroxycoumarin glucuronide sodium salt, 5 mg | sc-252309 | 5 mg | $1200.00 |