Molecular structure of 7-Hydroxyaristolochic acid A, CAS Number: 79185-75-4
7-Hydroxyaristolochic acid A (CAS 79185-75-4)
Application:
7-Hydroxyaristolochic acid A is an aristolochic acid associated with urothelial carcinoma formation
CAS Number:
79185-75-4
Molecular Weight:
357.27
Molecular Formula:
C17H11NO8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
7-Hydroxyaristolochic acid A is an aristolochic acid. These compounds are the active ingredients, responsible for the hepatoxicity and renal toxicity, found in Aristolochic fangchi. They form DNA adducts in renal tissue and are associated with urothelial carcinoma formation.
7-Hydroxyaristolochic acid A (CAS 79185-75-4) References
- Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi). | Nortier, JL., et al. 2000. N Engl J Med. 342: 1686-92. PMID: 10841870
- Analysis of aristolochic acids and analogues in medicinal plants and their commercial products by HPLC-PAD-ESI/MS. | Wei, F., et al. 2005. Phytochem Anal. 16: 222-30. PMID: 15997857
- 32P-postlabelling analysis of the DNA adducts formed by aristolochic acid I and II. | Pfau, W., et al. 1990. Carcinogenesis. 11: 1627-33. PMID: 2401053
- Chemical profiling of principle active and toxic constituents in herbs containing aristolochic acids. | Yue, L., et al. 2024. Chin Herb Med. 16: 293-300. PMID: 38706826
- Induction of hepatic nodules in the rat by aristolochic acid. | Rossiello, MR., et al. 1993. Cancer Lett. 71: 83-7. PMID: 8364902
- Renal toxicity of aristolochic acid in rats as an example of nephrotoxicity testing in routine toxicology. | Mengs, U. and Stotzem, CD. 1993. Arch Toxicol. 67: 307-11. PMID: 8368940
- Effect of diallyl sulfide on aristolochic acid-induced forestomach carcinogenesis in rats. | Hadjiolov, D., et al. 1993. Carcinogenesis. 14: 407-10. PMID: 8453716
- Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy. | Schmeiser, HH., et al. 1996. Cancer Res. 56: 2025-8. PMID: 8616845
- Acute hepatitis in a patient using a Chinese herbal tea--a case report. | Levi, M., et al. 1998. Pharm World Sci. 20: 43-4. PMID: 9536471
- Minor aristolochic acids from Aristolochia argentina and mass spectral analysis of aristolochic acids. | Priestap, Horacio A. (1987). Phytochemistry 26.2. 518-529.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7-Hydroxyaristolochic acid A, 1 mg | sc-205588 | 1 mg | $250.00 | |||
7-Hydroxyaristolochic acid A, 5 mg | sc-205588A | 5 mg | $688.00 |