Molecular structure of 7-Hydroxy-DPAT·HBr, CAS Number: 76135-30-3
7-Hydroxy-DPAT·HBr (CAS 76135-30-3)
See product citations (5)
Application:
7-Hydroxy-DPAT⋅HBr is a selective dopamine D3 agonist
CAS Number:
76135-30-3
Purity:
98%
Molecular Weight:
328.3
Molecular Formula:
C16H25NO•HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
7-Hydroxy-DPAT·HBr is a selective D3DR (dopamine receptor) agonist that is primarily found in neurons of the brain. Upon activation by 7-Hydroxy-DPAT·HBr, D3DR′s exhibit a decrease in the release of dopamine from neurons and activate phospholipase D via formation of a complex with RhoA. In addition, studies suggest that 7-Hydroxy-DPAT·HBr induces the suppression of cAMP in hamster ovary cells. Since the D3DR is part of the D2DR subfamily, which includes the D2DR, D3DR, and D4DR receptors, ligands such as 7-Hydroxy-DPAT·HBr can also bind to D2DR at a higher concentration. 7-Hydroxy-DPAT·HBr is an activator of D2DR.
7-Hydroxy-DPAT·HBr (CAS 76135-30-3) References
- D3 dopamine receptor signals to activation of phospholipase D through a complex with Rho. | Everett, PB. and Senogles, SE. 2010. J Neurochem. 112: 963-71. PMID: 20021566
- A functional fast scan cyclic voltammetry assay to characterize dopamine D2 and D3 autoreceptors in the mouse striatum. | Maina, FK. and Mathews, TA. 2010. ACS Chem Neurosci. 1: 450-462. PMID: 20567609
- Pharmacological aspects of R-(+)-7-OH-DPAT, a putative dopamine D3 receptor ligand. | Damsma, G., et al. 1993. Eur J Pharmacol. 249: R9-10. PMID: 8287911
- Behavioural effects of the putative D-3 dopamine receptor agonist 7-OH-DPAT in relation to other 'D-2-like' agonists. | Daly, SA. and Waddington, JL. 1993. Neuropharmacology. 32: 509-10. PMID: 8321432
- Acute haloperidol attenuates the hypomotility induced with 7-hydroxy-DPAT. | Lynch, MR. and Ormsby, JL. 1997. Neuroreport. 8: 611-5. PMID: 9106733
- Distribution of dopamine D3 receptor expressing neurons in the human forebrain: comparison with D2 receptor expressing neurons. | Gurevich, EV. and Joyce, JN. 1999. Neuropsychopharmacology. 20: 60-80. PMID: 9885786
Inhibitor of:
DARPP-32.Activator of:
D2DR, and D3DR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7-Hydroxy-DPAT·HBr, 10 mg | sc-200400 | 10 mg | $104.00 | |||
7-Hydroxy-DPAT·HBr, 50 mg | sc-200400A | 50 mg | $250.00 |