7-Hydroxy-DPAT dot HBr CAS: 74938-11-7
MF: C16H25NO•HBr
MW: 328.3
A selective dopamine D3 agonist.

7-Hydroxy-DPAT·HBr (CAS 74938-11-7)

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Application: 7-Hydroxy-DPAT⋅HBr is a selective dopamine D3 agonist
CAS Number: 74938-11-7
Purity: 98%
Molecular Weight: 328.3
Molecular Formula: C16H25NO•HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

7-Hydroxy-DPAT·HBr is a selective D3DR (dopamine receptor) agonist that is primarily found in neurons of the brain. Upon activation by 7-Hydroxy-DPAT·HBr, D3DR's exhibit a decrease in the release of dopamine from neurons and activate phospholipase D via formation of a complex with RhoA. In addition, studies suggest that 7-Hydroxy-DPAT·HBr induces the suppression of cAMP in hamster ovary cells. Since the D3DR is part of the D2DR subfamily, which includes the D2DR, D3DR, and D4DR receptors, ligands such as 7-Hydroxy-DPAT·HBr can also bind to D2DR at a higher concentration. 7-Hydroxy-DPAT·HBr is an activator of D2DR.


References

1. Damsma, G., et al. 1993. Eur. J. Pharmacol. 249: R9-10. PMID: 8287911
2. Daly, S.A., et al 1993. Neuropharmacology. 32: 509-510. PMID: 8321432
3. Gurevich, E.V., et al. 1999. Neuropsychopharmacology. 20: 60-80. PMID: 9885786
4. Maina, F.K. and Mathews, T.A. 2010. ACS Chem Neurosci. 1: 450-462. PMID: 20567609
5. Everett, P.B. and Senogles, S.E. 2010. J. Neurochem. 112: 963-971. PMID: 20021566

Physical State :
Solid
Solubility :
Soluble in water, ethanol, and DMSO (100 mM).
Storage :
Store at room temperature
Melting Point :
168-170° C
Boiling Point :
383.8° C at 760 mmHg (Predicted)
Ki Data :
D3 dopamine receptor: Ki= 0.99 nM; D2 dopamine receptor: Ki= 10 nM; D1 dopamine receptor: Ki= ~ 5000 nM; D4 dopamine receptor: Ki= 650 nM
pK Values :
pKa: 10.39 (Predicted), pKb: 9.47 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
1219
MDL Number :
MFCD00153809
SMILES :
CCCN(CCC)C1CCC2=C(C1)C=C(C=C2)O

Download SDS (MSDS)

Certificate of Analysis

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7-Hydroxy-DPAT dot HBr (CAS 74938-11-7)  Product Citations

See how others have used 7-Hydroxy-DPAT dot HBr (CAS 74938-11-7). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 20021566  Everett, PB. et al. 2010. J. Neurochem. 112: 963-971.

PMID: # 7907989  MacKenzie, RG. et al. 1994. Eur. J. Pharmacol. 266: 79-85.

PMID: # 1518841  Lévesque, D. et al. 1992. Proc. Natl. Acad. Sci. U.S.A. 89: 8155-8159.

Citations 1 to 3 of 3 total
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