Molecular structure of 7-HC-arachidonate, CAS Number: 161180-11-6
7-HC-arachidonate (CAS 161180-11-6)
Alternate Names:
Umbelliferyl Arachidonate
Application:
7-HC-arachidonate is a PLA2 fluorogenic substrate
CAS Number:
161180-11-6
Purity:
98%
Molecular Weight:
448.6
Molecular Formula:
C29H36O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
7-HC-arachidonate is a PLA2 fluorogenic substrate for use in assays with phospholipid and Ca2+. It is for use with purified enzymes, as this substrate is nonspecific. 7-HC-arachidonate is ideal for drug discovery, HTS, and similar applications.
7-HC-arachidonate (CAS 161180-11-6) References
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- Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution. | Schalk-Hihi, C., et al. 2011. Protein Sci. 20: 670-83. PMID: 21308848
- Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors. | Cisneros, JA., et al. 2012. J Med Chem. 55: 824-36. PMID: 22185522
- Alterations in cerebrospinal fluid glycerophospholipids and phospholipase A2 activity in Alzheimer's disease. | Fonteh, AN., et al. 2013. J Lipid Res. 54: 2884-97. PMID: 23868911
- Amniotic fluid levels of phospholipase A2 in fetal rats with retinoic acid induced myelomeningocele: the potential 'second hit' in neurologic damage. | Agarwal, R., et al. 2016. J Matern Fetal Neonatal Med. 29: 3003-8. PMID: 26513600
- Group V Secreted Phospholipase A2 Induces the Release of Proangiogenic and Antiangiogenic Factors by Human Neutrophils. | Loffredo, S., et al. 2017. Front Immunol. 8: 443. PMID: 28458672
- Secreted Phospholipases A2 in Hereditary Angioedema With C1-Inhibitor Deficiency. | Loffredo, S., et al. 2018. Front Immunol. 9: 1721. PMID: 30083168
- Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders. | Deng, H. and Li, W. 2020. Acta Pharm Sin B. 10: 582-602. PMID: 32322464
- Angiopoietins, Vascular Endothelial Growth Factors and Secretory Phospholipase A2 in Ischemic and Non-Ischemic Heart Failure. | Varricchi, G., et al. 2020. J Clin Med. 9: PMID: 32575548
- A continuous fluorescence-based assay for the human high-molecular-weight cytosolic phospholipase A2. | Huang, Z., et al. 1994. Anal Biochem. 222: 110-5. PMID: 7856835
- Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine. | Pickard, RT., et al. 1996. J Biol Chem. 271: 19225-31. PMID: 8702602
Substrate of:
cPLA2, Enzyme, and Fluorogenic.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7-HC-arachidonate, 10 mg | sc-223738 | 10 mg | $101.00 | |||
7-HC-arachidonate, 50 mg | sc-223738A | 50 mg | $468.00 |