Molecular structure of 7-Ethyl-10-(4-N-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecin, CAS Number: 181467-56-1
7-Ethyl-10-(4-N-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecin (CAS 181467-56-1)
See product citations (1)
Alternate Names:
4-[(4-Carboxybutyl)amino]-1-piperidinecarboxylic acid; APC
Application:
7-Ethyl-10-(4-N-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecin is a major metabolite of Irinotecan
CAS Number:
181467-56-1
Molecular Weight:
618.68
Molecular Formula:
C33H38N4O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
7-Ethyl-10-(4-N-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecin is a major metabolite of Irinotecan (sc-269253). This modification enhances the molecule′s interaction with topoisomerase I, an essential enzyme involved in DNA replication. By inhibiting topoisomerase I, this metabolite prevents the relegation of single-strand DNA breaks, leading to DNA damage accumulation and cell cycle arrest.
7-Ethyl-10-(4-N-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecin (CAS 181467-56-1) References
- Pharmacovigilance of herb-drug interactions: A pharmacokinetic study on the combination administration of herbal Kang'ai injection and chemotherapy irinotecan hydrochloride injection by LC-MS/MS. | Chen, Y., et al. 2021. J Pharm Biomed Anal. 194: 113784. PMID: 33280996
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7-Ethyl-10-(4-N-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecin, 1 mg | sc-210614 | 1 mg | $433.00 |