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7-Ethoxy-4-(trifluoromethyl)coumarin (CAS 115453-82-2)

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Alternate Names:
Ethyl 4-(trifluoromethyl)umbelliferyl ether
CAS Number:
115453-82-2
Molecular Weight:
258.19
Molecular Formula:
C12H9F3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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7-Ethoxy-4-(trifluoromethyl)coumarin is a fluorescent probe. It is used to detect and measure the presence of certain enzymes and reactive oxygen species within cellular and molecular systems. The compound undergoes a specific chemical reaction with its target molecules, resulting in a measurable change in fluorescence that can be quantified and analyzed. The mechanism of action involves the interaction of the compound with the target molecules, leading to a change in its fluorescent properties.


7-Ethoxy-4-(trifluoromethyl)coumarin (CAS 115453-82-2) References

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  7. Effects of cytochrome P450 inhibitors on the biotransformation of fluorogenic substrates by adult male rat liver microsomes and cDNA-expressed rat cytochrome P450 isoforms.  |  Makaji, E., et al. 2010. Toxicol Sci. 113: 293-304. PMID: 19858067
  8. Long-term cultivation of HepG2 liver cells encapsulated in alginate hydrogels: a study of cell viability, morphology and drug metabolism.  |  Lan, SF., et al. 2010. Toxicol In Vitro. 24: 1314-23. PMID: 20171269
  9. Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme.  |  Wilderman, PR., et al. 2012. FEBS J. 279: 1607-20. PMID: 22051155
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  12. Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations.  |  Liu, J., et al. 2016. Biochemistry. 55: 1997-2007. PMID: 26982502
  13. Dose-response relationships for cytochrome P450 induction by phenobarbital in the cotton rat (Sigmodon hispidus).  |  Jones, CR., et al. 1998. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 121: 197-203. PMID: 9972461

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

7-Ethoxy-4-(trifluoromethyl)coumarin, 50 mg

sc-239119
50 mg
$257.00