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7-epi-Taxol (CAS 105454-04-4)

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Alternate Names:
7-Epipaclitaxel; 7-Epitaxol; 7-epi-Paclitaxel; Epitaxol
Application:
7-epi-Taxol is an antineoplastic compound
CAS Number:
105454-04-4
Purity:
≥95%
Molecular Weight:
853.91
Molecular Formula:
C47H51NO14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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7-epi-Taxol is a paclitaxel binds to tubulin, interfering with the normal function of microtubule. As a result the cell is unable to use its cytoskeleton in a flexible manner. The cell′s dynamic instability is interrupted. The compound 7-epi-Taxol has been isolated from Taxus brevifolia. 7-epi-Taxol also displays antineoplastic properties.


7-epi-Taxol (CAS 105454-04-4) References

  1. [Studies of the mechanism of 7-epi-taxol converted to taxol from Taxus extract catalyzed with Al2O3].  |  Zhang, ZQ. and Su, ZG. 2000. Sheng Wu Gong Cheng Xue Bao. 16: 378-82. PMID: 11059285
  2. Mechanism of action of taxol.  |  Horwitz, SB. 1992. Trends Pharmacol Sci. 13: 134-6. PMID: 1350385
  3. 1H- and 13C-nmr assignments for taxol, 7-epi-taxol, and cephalomannine.  |  Chmurny, GN., et al. 1992. J Nat Prod. 55: 414-23. PMID: 1355110
  4. Production of biologically active taxoids by a callus culture of Taxus cuspidata.  |  Bai, J., et al. 2004. J Nat Prod. 67: 58-63. PMID: 14738387
  5. The chemistry of taxol.  |  Kingston, DG. 1991. Pharmacol Ther. 52: 1-34. PMID: 1687170
  6. Degradation of paclitaxel and related compounds in aqueous solutions I: epimerization.  |  Tian, J. and Stella, VJ. 2008. J Pharm Sci. 97: 1224-35. PMID: 17680660
  7. Degradation of paclitaxel and related compounds in aqueous solutions II: Nonepimerization degradation under neutral to basic pH conditions.  |  Tian, J. and Stella, VJ. 2008. J Pharm Sci. 97: 3100-8. PMID: 17963215
  8. α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana.  |  Dang, PH., et al. 2017. J Nat Prod. 80: 1087-1095. PMID: 28240909
  9. Molecular docking of potential inhibitors with the mTOR protein.  |  Fathima, JS., et al. 2021. Bioinformation. 17: 212-217. PMID: 34393439
  10. Developed network between taxoid and phenylpropanoid pathways in Cryptosporiopsis tarraconensis, taxan-producing endophytic fungus by Debiased Sparse Partial Correlation (DSPC) algorithm.  |  Mohammadi Ballakuti, N. and Ghanati, F. 2023. PLoS One. 18: e0282010. PMID: 36821563
  11. Taxol-induced polymerization of purified tubulin. Mechanism of action.  |  Kumar, N. 1981. J Biol Chem. 256: 10435-41. PMID: 6116707
  12. A new large-scale process for taxol and related taxanes from Taxus brevifolia.  |  Rao, KV., et al. 1995. Pharm Res. 12: 1003-10. PMID: 7494794
  13. Peptidomimetics derived from natural products.  |  Wiley, RA. and Rich, DH. 1993. Med Res Rev. 13: 327-84. PMID: 8483337
  14. Solidification studies of polyethylene glycols, gelucire 44/14 or their dispersions with triamterene or temazepam.  |  Dordunoo, SK., et al. 1996. J Pharm Pharmacol. 48: 782-9. PMID: 8887725

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

7-epi-Taxol, 500 µg

sc-202894B
500 µg
$70.00

7-epi-Taxol, 1 mg

sc-202894C
1 mg
$115.00

7-epi-Taxol, 5 mg

sc-202894
5 mg
$350.00

7-epi-Taxol, 10 mg

sc-202894A
10 mg
$578.00