Molecular structure of 7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin, CAS Number: 76877-33-3
7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin (CAS 76877-33-3)
Alternate Names:
CPM
Application:
7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin is a thiol-reactive fluorescent probe
CAS Number:
76877-33-3
Molecular Weight:
402.44
Molecular Formula:
C24H22N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A thiol-reactive fluorescent probe. 7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin (CPM) selectively forms Michael adducts in the presence of hyperreactive sulfhydryls. CPM has been used to monitor the release of thiols, quantitate thiol in microplate reactions, and to distinguish proliferating cancer cells by nucleolar protein staining.
7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin (CAS 76877-33-3) References
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- Refolding and characterization of two G protein-coupled receptors purified from E. coli inclusion bodies. | Heim, B., et al. 2021. PLoS One. 16: e0247689. PMID: 33626080
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- Molecular interaction between ryanodine receptor and glycoprotein triadin involves redox cycling of functionally important hyperreactive sulfhydryls. | Liu, G. and Pessah, IN. 1994. J Biol Chem. 269: 33028-34. PMID: 7806531
- Direct evidence for the existence and functional role of hyperreactive sulfhydryls on the ryanodine receptor-triadin complex selectively labeled by the coumarin maleimide 7-diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin. | Liu, G., et al. 1994. Mol Pharmacol. 45: 189-200. PMID: 8114670
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin, 25 mg | sc-214399 | 25 mg | $262.00 |