7-Deacetyl-7-O-hemisuccinyl-Forskolin (CAS 83797-56-2)

7-Deacetyl-7-O-hemisuccinyl-Forskolin (7-DHSF) is a synthetic derivative of Forskolin, a labdane diterpenoid found in the plant Coleus forskohlii, that can be readily activated and used for preparation of affinity supports and probes. It can be coupled to aminoethyl-agarose via its N-hydroxysuccinimide ester. The immobilized derivative can be used to purify adenylate cyclase. 7-Deacetyl-7-O-hemisuccinyl-Forskolin is a potent activator of adenylate cyclase, an enzyme that catalyzes the formation of the secondary messenger cyclic AMP (cAMP) from ATP. 7-Deacetyl-7-O-hemisuccinyl-Forskolin is widely used in laboratory experiments and scientific research due to its ability to modulate various metabolic pathways and its ability to penetrate cell membranes. For example, it is employed to study the effects of cAMP on gene expression, cell cycle progression and apoptosis, and signal transduction pathways, as well as the regulation of various enzymes, hormones, and neurotransmitters.