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7-Aminoquinoline (CAS 580-19-8)

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Alternate Names:
Quinolin-7-amine
CAS Number:
580-19-8
Molecular Weight:
144.17
Molecular Formula:
C9H8N2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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7-Aminoquinoline is an organic compound renowned for its diverse applications in the synthesis of dyes and other organic compounds. As a key constituent in the synthesis of various organic compounds, 7-Aminoquinoline serves as a building block, finding utility in numerous chemical reactions. Moreover, it assumes the role of a ligand in coordination chemistry, fostering complex formations. Acting as a proton acceptor, 7-Aminoquinoline readily donates electrons, leading to the formation of a resonance-stabilized cation. This cationic species, in turn, engages in reactions with other molecules, including transition metal complexes, giving rise to stable and well-defined complexes.


7-Aminoquinoline (CAS 580-19-8) References

  1. A new synthesis of 7,8-diaminoquinoline.  |  LINSKER, F. and EVANS, RL. 1946. J Am Chem Soc. 68: 149. PMID: 21008339
  2. 7-Aminoquinolines. A novel class of agents active against herpesviruses.  |  Nasr, M., et al. 1988. J Med Chem. 31: 1347-51. PMID: 2838633
  3. Quinoline-Derived Two-Photon-Sensitive Octupolar Probes.  |  Dunkel, P., et al. 2017. ChemistryOpen. 6: 660-667. PMID: 29046861
  4. Catalytic-Type Excited-State N-H Proton-Transfer Reaction in 7-Aminoquinoline and Its Derivatives.  |  Chang, KH., et al. 2019. Chemistry. 25: 14972-14982. PMID: 31509279
  5. Cyano Derivatives of 7-Aminoquinoline That Are Highly Emissive in Water: Potential for Sensing Applications.  |  Chang, KH., et al. 2021. Chemistry. 27: 8040-8047. PMID: 33904607
  6. The circular dichroism in the ultraviolet of aminoacridines and ethidium bromide bound to DNA.  |  Dalgleish, DG. and Peacocke, AR. 1971. Biopolymers. 10: 1853-63. PMID: 5165064
  7. Determination of time course of tablet disintegration II: Method using continuous functions.  |  Nelson, KG. and Wang, LY. 1978. J Pharm Sci. 67: 86-9. PMID: 619120
  8. Binding of 3-aminoacridinium and 7-aminoquinolinium monocations to double-stranded DNA: evidence for nonlinear binding isotherm in intercalative region.  |  Capomacchia, AC. and Schulman, SG. 1978. J Pharm Sci. 67: 89-94. PMID: 619121
  9. In search of anti-Trypanosoma cruzi drugs: new leads from a mouse model.  |  Kinnamon, KE., et al. 1977. J Med Chem. 20: 741-4. PMID: 69024
  10. Synthesis and properties of fluorine-containing heterocyclic compounds. V. Trifluoromethyl-1,8- and 1,10-phenanthrolines†  |   and Edwin B. Nyquist, Madeleine M. Joullié. December 1967. Journal of Heterocyclic Chemistry. Volume4, Issue4: Pages 539-545.
  11. Chirality of intermediates in thiamin catalysis: structure of (+)-2-(1-hydroxyethyl)-3,4-dimethyl-5-(2-hydroxyethyl)thiazolium iodide, the absolute stereochemistry of the enantiomers of 2-(1-hydroxyethyl)thiamin, and enzymic reaction of the diphosphates  |  Ronald Kluger, Khashayar Karimian, Gerald Gish, Walter A. Pangborn, and George T. DeTitta. 1987,. J. Am. Chem. Soc.,. 109, 2: 618–620.
  12. Uncatalyzed, on water oxygenative cleavage of inert C–N bond with concomitant 8,7-amino shift in 8-aminoquinoline derivatives†‡  |  Vinayak Botla,a NavyaSree Pilliab and Chandrasekharam Malapaka ORCID logo *ab. 2019,. Green Chem.,. 21,: 1735-1742.
  13. Substituents effect on the methanol-assisted excited-state intermolecular proton transfer of 7-Aminoquinoline: A theoretical study  |  Z Li, Z Tang, W Li, H Zhan, X Liu, Y Wang, J Tian… - Journal of Molecular …, 2021 - Elsevier. 1 November 2021,. Journal of Molecular Liquids. Volume 341,: 116920.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

7-Aminoquinoline, 250 mg

sc-482645
250 mg
$153.00