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7-Aminodesacetoxycephalosporanic Acid (CAS 22252-43-3)

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Alternate Names:
7-Amino-3-deacetoxycephalosporanic Acid
Application:
7-Aminodesacetoxycephalosporanic Acid is a Cephalexin metabolite.
CAS Number:
22252-43-3
Purity:
≥98%
Molecular Weight:
214.24
Molecular Formula:
C8H10N2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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CAS: 22252-43-3 corresponds to Iprodione, a synthetic compound primarily used in agricultural settings as a fungicide. Iprodione functions by inhibiting the germination of fungal spores and blocking mycelial growth through disruption of the synthesis of fungal cell wall components. Specifically, Iprodione targets the biosynthesis of glycerol, which is a critical component of the fungal cell membrane and wall. By interfering with glycerol production, Iprodione compromises the structural integrity of the fungal cell wall, ultimately leading to the cessation of fungal development and death of the organism. This mode of action is exploited in research environments to study fungal biology and the mechanisms of action of fungicidal agents. The chemical′s role in inhibiting specific pathways offers insights into fungal cell wall biosynthesis and the potential points of vulnerability in fungal organisms. Research involving Iprodione helps to explain the complex interactions between fungal pathogens and antifungal compounds, advancing the understanding of fungal resistance mechanisms and contributing to the development of more effective fungicidal strategies. This type of research is crucial for improving crop protection techniques, ensuring food security, and managing environmental impacts of fungal diseases.


7-Aminodesacetoxycephalosporanic Acid (CAS 22252-43-3) References

  1. Kinetics of enzyme acylation and deacylation in the penicillin acylase-catalyzed synthesis of beta-lactam antibiotics.  |  Alkema, WB., et al. 2003. Eur J Biochem. 270: 3675-83. PMID: 12950251
  2. Molecular biology of β-lactam acylases.  |  Deshpande, BS., et al. 1994. World J Microbiol Biotechnol. 10: 129-38. PMID: 24420933
  3. Computational design of cephradine synthase in a new scaffold identified from structural databases.  |  Huang, X., et al. 2017. Chem Commun (Camb). 53: 7604-7607. PMID: 28639649
  4. Substructure Reactivity Affecting the Manganese Dioxide Oxidation of Cephalosporins.  |  Hsu, MH., et al. 2018. Environ Sci Technol. 52: 9188-9195. PMID: 30039964
  5. Directed evolution of a penicillin V acylase from Bacillus sphaericus to improve its catalytic efficiency for 6-APA production.  |  Xu, G., et al. 2018. Enzyme Microb Technol. 119: 65-70. PMID: 30243389
  6. Metallocenyl 7-ACA Conjugates: Antibacterial Activity Studies and Atomic-Resolution X-ray Crystal Structure with CTX-M β-Lactamase.  |  Lewandowski, EM., et al. 2020. Chembiochem. 21: 2187-2195. PMID: 32182393
  7. Laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acid.  |  Mikolasch, A., et al. 2020. AMB Express. 10: 177. PMID: 33006678
  8. Selectivity and kinetic modeling of penicillin G acylase variants for the synthesis of cephalexin under a broad range of substrate concentrations.  |  Harris, PR., et al. 2022. Biotechnol Bioeng. 119: 3117-3126. PMID: 36030473

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

7-Aminodesacetoxycephalosporanic Acid, 50 mg

sc-207152
50 mg
$60.00

7-Aminodesacetoxycephalosporanic Acid, 500 mg

sc-207152A
500 mg
$200.00