Molecular structure of 7,8-Dihydro-L-biopterin, CAS Number: 6779-87-9
7,8-Dihydro-L-biopterin (CAS 6779-87-9)
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Alternate Names:
BH2; Dihydrobiopterin; Quinonoid dihydrobiopterin
Application:
7,8-Dihydro-L-biopterin is a precursor of BH4 synthesis
CAS Number:
6779-87-9
Purity:
≥98%
Molecular Weight:
239.23
Molecular Formula:
C9H13N5O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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The compound 7,8-Dihydro-L-biopterin, also referred to as 7,8-dihydropterin, 7,8-DHP, or DHB, is a cofactor required for the synthesis of key neurotransmitters. These neurotransmitters, such as serotonin, dopamine, and norepinephrine. Additionally, 7,8-Dihydro-L-biopterin acts as a precursor to tetrahydrobiopterin (BH4), which is necessary for the production of nitric oxide and other reactive oxygen species. 7,8-Dihydro-L-biopterin is also involved in the breakdown of serotonin and dopamine by monoamine oxidase (MAO).
7,8-Dihydro-L-biopterin (CAS 6779-87-9) References
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- Crystal structure and site-specific mutagenesis of pterin-bound human phenylalanine hydroxylase. | Erlandsen, H., et al. 2000. Biochemistry. 39: 2208-17. PMID: 10694386
- Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates. | Erlandsen, H., et al. 2002. J Mol Biol. 320: 645-61. PMID: 12096915
- Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin. | Wang, L., et al. 2002. Biochemistry. 41: 12569-74. PMID: 12379098
- Structural studies on phenylalanine hydroxylase and implications toward understanding and treating phenylketonuria. | Erlandsen, H., et al. 2003. Pediatrics. 112: 1557-65. PMID: 14654665
- A simple two step procedure for purification of the catalytic domain of chicken tryptophan hydroxylase 1 in a form suitable for crystallization. | Nielsen, MS., et al. 2008. Protein Expr Purif. 57: 116-26. PMID: 18055219
- Neopterin, a marker of immune response, and 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress, correlate at high age as determined by automated simultaneous high-performance liquid chromatography analysis of human urine. | Svoboda, P., et al. 2008. Anal Biochem. 383: 236-42. PMID: 18822267
- Asymmetric uptake of sepiapterin and 7,8-dihydrobiopterin as a gateway of the salvage pathway of tetrahydrobiopterin biosynthesis from the lumenal surface of rat endothelial cells. | Ohashi, A., et al. 2011. Mol Genet Metab. 104: 404-6. PMID: 21704545
- Simultaneous quantification of tetrahydrobiopterin, dihydrobiopterin, and biopterin by liquid chromatography coupled electrospray tandem mass spectrometry. | Fismen, L., et al. 2012. Anal Biochem. 430: 163-70. PMID: 22940649
- Host metabolism regulates intracellular growth of Trypanosoma cruzi. | Caradonna, KL., et al. 2013. Cell Host Microbe. 13: 108-17. PMID: 23332160
- Photooxidation of tetrahydrobiopterin under UV irradiation: possible pathways and mechanisms. | Buglak, AA., et al. 2014. Photochem Photobiol. 90: 1017-26. PMID: 24773158
- A conserved acidic residue in phenylalanine hydroxylase contributes to cofactor affinity and catalysis. | Ronau, JA., et al. 2014. Biochemistry. 53: 6834-48. PMID: 25295853
- Metabonomic Insights into the Sperm Activation Mechanisms in Ricefield Eel (Monopterus albus). | Zhang, H., et al. 2020. Genes (Basel). 11: PMID: 33114541
- A Landscape of Metabonomics for Intermingled Phlegm and Blood Stasis and Its Concurrent Syndromes in Stable Angina Pectoris of Coronary Heart Disease. | Zheng, L., et al. 2022. Front Cardiovasc Med. 9: 871142. PMID: 35647058
Inhibitor of:
GCH-I.Activator of:
GFRP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7,8-Dihydro-L-biopterin, 10 mg | sc-202895 | 10 mg | $224.00 | |||
7,8-Dihydro-L-biopterin, 50 mg | sc-202895A | 50 mg | $422.00 |