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7,8-Dihydro-D-Neopterin (CAS 1218-98-0)

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Alternate Names:
7,8-Dihydroneopterin; Dihydroneopterin
Application:
7,8-Dihydro-D-Neopterin is an intermediate in the biosynthesis of tetrahydrobiopterin
CAS Number:
1218-98-0
Molecular Weight:
255.2
Molecular Formula:
C9H13N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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7,8-Dihydro-D-Neopterin is involved in the biosynthesis of tetrahydrobiopterin, a cofactor for aromatic amino acid hydroxylases and nitric oxide synthases. It is a precursor for the de novo synthesis of tetrahydrobiopterin. 7,8-Dihydro-D-Neopterin is converted to neopterin by the enzyme neopterin synthase, which is a key step in the biosynthetic pathway. 7,8-Dihydro-D-Neopterin plays a role in the regulation of cellular processes that require tetrahydrobiopterin as a cofactor, such as the production of neurotransmitters and nitric oxide. Its mechanism of action involves participating in redox reactions and serving as a cofactor for enzymes involved in the metabolism of aromatic amino acids.


7,8-Dihydro-D-Neopterin (CAS 1218-98-0) References

  1. Reduced pteridine derivatives induce apoptosis in human neuronal NT2/HNT cells.  |  Spöttl, N., et al. 2000. Immunobiology. 201: 478-91. PMID: 10776802
  2. Reduced pteridine derivatives induce apoptosis in PC12 cells.  |  Enzinger, C., et al. 2002. Neurochem Int. 41: 71-8. PMID: 11918974
  3. Enzymatic assimilation of cyanide via pterin-dependent oxygenolytic cleavage to ammonia and formate in Pseudomonas fluorescens NCIMB 11764.  |  Fernandez, RF., et al. 2004. Appl Environ Microbiol. 70: 121-8. PMID: 14711633
  4. Biosynthesis of tetrahydrofolate in plants: crystal structure of 7,8-dihydroneopterin aldolase from Arabidopsis thaliana reveals a novel adolase class.  |  Bauer, S., et al. 2004. J Mol Biol. 339: 967-79. PMID: 15165863
  5. Mechanism of dihydroneopterin aldolase: functional roles of the conserved active site glutamate and lysine residues.  |  Wang, Y., et al. 2006. Biochemistry. 45: 15232-9. PMID: 17176045
  6. Mechanism of dihydroneopterin aldolase. NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes.  |  Wang, Y., et al. 2007. FEBS J. 274: 2240-52. PMID: 17388809
  7. An Fe2+-dependent cyclic phosphodiesterase catalyzes the hydrolysis of 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate in methanopterin biosynthesis.  |  Mashhadi, Z., et al. 2009. Biochemistry. 48: 9384-92. PMID: 19746965
  8. Production and analytical characterization of neopterin immunoreagents for biosensor developments.  |  Cernoch, I., et al. 2011. Anal Bioanal Chem. 399: 979-86. PMID: 21088828
  9. Neopterin derivatives together with cyclic guanosine monophosphate induce c-fos gene expression.  |  Uberall, F., et al. 1994. FEBS Lett. 352: 11-4. PMID: 7925931

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

7,8-Dihydro-D-Neopterin, 10 mg

sc-202431
10 mg
$100.00