7-(4-acetylpiperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 74011-56-6)
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7-(4-acetylpiperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid functions as an inhibitor of bacterial DNA gyrase, a type II topoisomerase enzyme. It exerts its mechanism of action by binding to the ATP-binding site of DNA gyrase, preventing the enzyme from catalyzing the negative supercoiling of DNA. This interference with DNA gyrase activity ultimately leads to the accumulation of double-stranded breaks in bacterial DNA, inhibiting DNA replication and transcription. As a result, the compound exhibits bactericidal activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Its mechanism of action may be useful for studying bacterial DNA gyrase and exploring potential strategies for combating antibiotic resistance.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7-(4-acetylpiperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, 1 g | sc-278577 | 1 g | $143.00 |