6′-Iodoresiniferatoxin (CAS 335151-55-8)
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6′-Iodoresiniferatoxin is a chemical analog of resiniferatoxin that is utilized in research due to its ability to modulate transient receptor potential vanilloid 1 (TRPV1) channels. This compound serves as useful for scientists exploring the structure-function relationship of TRPV1 channels, which are involved in sensing heat and pain. By binding to these channels, 6′-Iodoresiniferatoxin helps to elucidate their role in nociception and neurogenic inflammation. It is also used in studies investigating the potential desensitization effects on sensory neurons, which can provide insights into the molecular mechanisms of pain signaling. Additionally, the iodine moiety of 6′-Iodoresiniferatoxin makes it useful for radiolabeling experiments, allowing researchers to track and image the distribution of TRPV1 receptors in biological tissues.
6′-Iodoresiniferatoxin (CAS 335151-55-8) References
- Synthesis and in vitro evaluation of a novel iodinated resiniferatoxin derivative that is an agonist at the human vanilloid VR1 receptor. | McDonnell, ME., et al. 2002. Bioorg Med Chem Lett. 12: 1189-92. PMID: 11934585
- The taming of capsaicin. Reversal of the vanilloid activity of N-acylvanillamines by aromatic iodination. | Appendino, G., et al. 2005. J Med Chem. 48: 4663-9. PMID: 16000002
- Low Frequency Electroacupuncture Alleviated Spinal Nerve Ligation Induced Mechanical Allodynia by Inhibiting TRPV1 Upregulation in Ipsilateral Undamaged Dorsal Root Ganglia in Rats. | Jiang, YL., et al. 2013. Evid Based Complement Alternat Med. 2013: 170910. PMID: 23935654
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6′-Iodoresiniferatoxin, 1 mg | sc-202025 | 1 mg | $472.00 |