Date published: 2025-12-5

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6β-Hydroxy-7α-(thiomethyl) spironolactone (CAS 42219-60-3)

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Alternate Names:
(6β,7α,17α)-6,17-Dihydroxy-7-(methylthio)-3-oxo-pregn-4-ene-21-carboxylic Acid γ-Lactone
Application:
6β-Hydroxy-7α-(thiomethyl) spironolactone is a metabolite of Spironolactone
CAS Number:
42219-60-3
Molecular Weight:
404.56
Molecular Formula:
C23H32O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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6β-Hydroxy-7α-(thiomethyl) spironolactone, also known as 6beta-Hydroxy-7alpha-thiomethylspirolactone (6β-OH-7α-thio-MSP), is a small molecule that has garnered attention for its potential applications. Derived from spirolactone, a lactone ring in various compounds. The scientific community has recognized several potential applications of 6β-Hydroxy-7α-(thiomethyl) spironolactone. 6β-Hydroxy-7α-(thiomethyl) spironolactone contributes to the examination of hormone effects, such as melatonin, as well as the impacts of dietary supplements like omega-3 fatty acids. Although the precise mechanism of action of 6β-Hydroxy-7α-(thiomethyl) spironolactone remains incompletely understood, it is believed to bind to certain proteins and modulate their activity. For instance, 6β-Hydroxy-7α-(thiomethyl) spironolactone exhibits binding affinity to and activation of cyclooxygenase-2 (COX-2), an enzyme associated with inflammation and pain. It has interacted with and activate 5-lipoxygenase (5-LOX), an enzyme involved in the production of specific hormones.


6β-Hydroxy-7α-(thiomethyl) spironolactone (CAS 42219-60-3) References

  1. Effects of spironolactone on human blood mononuclear cells: mineralocorticoid receptor independent effects on gene expression and late apoptosis induction.  |  Sønder, SU., et al. 2006. Br J Pharmacol. 148: 46-53. PMID: 16520746
  2. Microbial synthesis of mammalian metabolites of spironolactone by thermophilic fungus Thermomyces lanuginosus.  |  B, S., et al. 2018. Steroids. 136: 1-7. PMID: 29803817

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

6β-Hydroxy-7α-(thiomethyl) spironolactone, 1 mg

sc-210569
1 mg
$638.00