Molecular structure of 6α-Prostaglandin I1, CAS Number: 62777-90-6
6α-Prostaglandin I1 (CAS 62777-90-6)
Alternate Names:
6α-PGI1 5,6α-dihydro PGI2
Application:
6α-Prostaglandin I1 is stable Prostaglandin I2 analog.
CAS Number:
62777-90-6
Molecular Weight:
354.5
Molecular Formula:
C20H34O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting the response.1 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI2 (0.4 ng/ml).2
6α-Prostaglandin I1 (CAS 62777-90-6) References
1 Patrono, C., Rotella, C.M., Toccafondi, R.S., et al. Prostacyclin stimulates the adenylate cyclase system of human thyroid tissue. Prostaglandins 22(1) 105-115 (1981). 2 Whittle, B.J.R., Moncada, S. Prostacyclin and its analogues for the therapy of thOrdering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6α-Prostaglandin I1, 1 mg | sc-205163 | 1 mg | $60.00 | |||
6α-Prostaglandin I1, 5 mg | sc-205163A | 5 mg | $272.00 |