6α-Hydroxy Paclitaxel-d5 (CAS 1315376-90-9)
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6α-Hydroxy Paclitaxel-d5 is a deuterated derivative of paclitaxel intended primarily for analytical applications, particularly in mass spectrometry. This modification involves the substitution of hydrogen atoms with deuterium (d5), enhancing the molecular stability and reducing isotopic exchange in complex biological matrices. Such stability is for accurate quantification and tracking of paclitaxel metabolites in research applications. The deuterated form does not differ significantly in chemical behavior from non-deuterated forms, making it an ideal internal standard for studies focusing on the metabolic pathways of paclitaxel. It allows for precise monitoring of the metabolic breakdown and distribution of paclitaxel-related compounds in experimental models.
6α-Hydroxy Paclitaxel-d5 (CAS 1315376-90-9) References
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- A dried blood spot assay for paclitaxel and its metabolites. | Xie, F., et al. 2018. J Pharm Biomed Anal. 148: 307-315. PMID: 29078175
- Taxol metabolism in rat hepatocytes. | Walle, T., et al. 1993. Biochem Pharmacol. 46: 1661-4. PMID: 7902091
- Isolation, structural determination, and biological activity of 6 alpha-hydroxytaxol, the principal human metabolite of taxol. | Harris, JW., et al. 1994. J Med Chem. 37: 706-9. PMID: 7907372
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6α-Hydroxy Paclitaxel-d5, 500 µg | sc-217406 | 500 µg | $1498.00 |