Molecular structure of 6α-Hydroxy Paclitaxel, CAS Number: 153212-75-0
6α-Hydroxy Paclitaxel (CAS 153212-75-0)
See product citations (19)
Application:
6α-Hydroxy Paclitaxel is a primary human metabolite of Paclitaxel
CAS Number:
153212-75-0
Purity:
≥98%
Molecular Weight:
869.91
Molecular Formula:
C47H51NO15
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
6α-Hydroxy Paclitaxel is a primary human metabolite of Paclitaxel. 6α-Hydroxy Paclitaxel is thought to function by attaching to tubulin and preventing the formation of microtubules, ultimately causing cell cycle interruption and cell death. Moreover, studies have demonstrated that 6α-Hydroxy Paclitaxel prompts the activation of various genes related to the regulation of cell cycle, apoptosis, and other biological mechanisms.
6α-Hydroxy Paclitaxel (CAS 153212-75-0) References
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- CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population. | Saito, Y., et al. 2007. Pharmacogenet Genomics. 17: 461-71. PMID: 17558302
- Effect of commonly used organic solvents on the kinetics of cytochrome P450 2B6- and 2C8-dependent activity in human liver microsomes. | Vuppugalla, R., et al. 2007. Drug Metab Dispos. 35: 1990-5. PMID: 17709370
- Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism. | Rodríguez-Antona, C., et al. 2008. Pharmacogenomics J. 8: 268-77. PMID: 17923851
- In vitro metabolism of 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid (licofelone, ML3000), an inhibitor of cyclooxygenase-1 and -2 and 5-lipoxygenase. | Albrecht, W., et al. 2008. Drug Metab Dispos. 36: 894-903. PMID: 18268076
- Relevance of nonsynonymous CYP2C8 polymorphisms to 13-cis retinoic acid and paclitaxel hydroxylation. | Rowbotham, SE., et al. 2010. Drug Metab Dispos. 38: 1261-6. PMID: 20421446
- Inhibition of cytochrome P450 2C8-mediated drug metabolism by the flavonoid diosmetin. | Quintieri, L., et al. 2011. Drug Metab Pharmacokinet. 26: 559-68. PMID: 21791871
- P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel. | Hendrikx, JJ., et al. 2013. Int J Cancer. 132: 2439-47. PMID: 23090875
- Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. | Yu, L., et al. 2013. Biopharm Drug Dispos. 34: 278-87. PMID: 23536207
- Alteration in the Plasma Concentrations of Endogenous Organic Anion-Transporting Polypeptide 1B Biomarkers in Patients with Non-Small Cell Lung Cancer Treated with Paclitaxel. | Mori, D., et al. 2020. Drug Metab Dispos. 48: 387-394. PMID: 32114508
- A phase Ib study of Oraxol (oral paclitaxel and encequidar) in patients with advanced malignancies. | Ma, WW., et al. 2022. Cancer Chemother Pharmacol. 90: 7-17. PMID: 35731258
- Taxol metabolism in rat hepatocytes. | Walle, T., et al. 1993. Biochem Pharmacol. 46: 1661-4. PMID: 7902091
- 6 alpha-Hydroxytaxol: isolation and identification of the major metabolite of taxol in human liver microsomes. | Kumar, GN., et al. 1994. Drug Metab Dispos. 22: 177-9. PMID: 7908626
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6α-Hydroxy Paclitaxel, 1 mg | sc-210577 | 1 mg | $580.00 |