Molecular structure of 6-Thioxanthine, CAS Number: 2002-59-7
6-Thioxanthine (CAS 2002-59-7)
Alternate Names:
1,3,6,9-Tetrahydro-6-thioxo-2H-purin-2-one; 2-Hydroxy-6-mercaptopurine
CAS Number:
2002-59-7
Molecular Weight:
168.18
Molecular Formula:
C5H4N4OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Belonging to the xanthine family, which includes caffeine and theobromine, 6-Thioxanthine is an organic compound. It serves as a valuable research tool in biochemical and physiological investigations, attributed to its ability to inhibit specific enzymes and proteins. Moreover, 6-Thioxanthine has been observed to impact the activity of certain neurotransmitters, suggesting its potential role as an agonist or antagonist for these neurotransmitters.
6-Thioxanthine (CAS 2002-59-7) References
- Assay of 6-mercaptopurine and its metabolites in patient plasma by high-performance liquid chromatography with diode-array detection. | Su, Y., et al. 1999. J Chromatogr B Biomed Sci Appl. 732: 459-68. PMID: 10517368
- Toxoplasma gondii: mechanism of the parasitostatic action of 6-thioxanthine. | Pfefferkorn, ER., et al. 2001. Exp Parasitol. 99: 235-43. PMID: 11888251
- THE BIOCHEMICAL BASIS FOR THE DIFFERENTIAL SENSITIVITY OF INTESTINAL MUCOSA AND BONE MARROW TO 6-THIOGUANINE. | MARCHESI, SL. and SARTORELLI, AC. 1963. Cancer Res. 23: 1769-73. PMID: 14082871
- In vitro study of 6-mercaptopurine oxidation catalysed by aldehyde oxidase and xanthine oxidase. | Rashidi, MR., et al. 2007. Drug Metab Pharmacokinet. 22: 299-306. PMID: 17827784
- In vitro oxidative metabolism of 6-mercaptopurine in human liver: insights into the role of the molybdoflavoenzymes aldehyde oxidase, xanthine oxidase, and xanthine dehydrogenase. | Choughule, KV., et al. 2014. Drug Metab Dispos. 42: 1334-40. PMID: 24824603
- 6-Mercaptopurine: total body autoradiograms and plasma concentration-time curves of 6MP and metabolites from marmoset monkeys. | Schouten, TJ., et al. 1986. Pediatr Hematol Oncol. 3: 159-65. PMID: 3153226
- Selection against expression of the Escherichia coli gene gpt in hprt+ mouse teratocarcinoma and hybrid cells. | Besnard, C., et al. 1987. Mol Cell Biol. 7: 4139-41. PMID: 3323888
- Electrochemistry/thermospray/tandem mass spectrometry in the study of biooxidation of purines. | Volk, KJ., et al. 1988. Anal Chem. 60: 720-2. PMID: 3382022
- Reactions of some 8-(3-pyridyl)-6-thioxanthines with methyl iodide. | Kleiner, M. 1973. J Chem Soc Perkin 1. 7: 739-43. PMID: 4736203
- Phase II evaluation and plasma pharmacokinetics of high-dose intravenous 6-thioguanine in patients with colorectal carcinoma. | Konits, PH., et al. 1982. Cancer Chemother Pharmacol. 8: 199-203. PMID: 7105383
- Toxoplasma gondii: characterization of a mutant resistant to 6-thioxanthine. | Pfefferkorn, ER. and Borotz, SE. 1994. Exp Parasitol. 79: 374-82. PMID: 7957757
- Escherichia coli gpt gene sensitizes rat glioma cells to killing by 6-thioxanthine or 6-thioguanine. | Tamiya, T., et al. 1996. Cancer Gene Ther. 3: 155-62. PMID: 8725879
- Regression of experimental brain tumors with 6-thioxanthine and Escherichia coli gpt gene therapy. | Ono, Y., et al. 1997. Hum Gene Ther. 8: 2043-55. PMID: 9414253
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6-Thioxanthine, 100 mg | sc-472656 | 100 mg | $281.00 | |||
6-Thioxanthine, 250 mg | sc-472656A | 250 mg | $547.00 | |||
6-Thioxanthine, 500 mg | sc-472656B | 500 mg | $988.00 | |||
6-Thioxanthine, 1 g | sc-472656C | 1 g | $1884.00 | |||
6-Thioxanthine, 2.5 g | sc-472656D | 2.5 g | $4120.00 |