6-Thioguanosine-5′-O-triphosphate sodium salt (CAS 17670-19-8)

6-Thioguanosine-5′-O-triphosphate sodium salt (6-TGTP) is a naturally occurring nucleotide found universally in cellular organisms. Derived from guanosine, a nucleoside fundamental to DNA and RNA, 6-Thioguanosine-5′-O-triphosphate sodium salt serves as a modified form. Its significance lies in being an essential intermediary in nucleotide synthesis and a key regulator of gene expression. Furthermore, it exhibits various biochemical and physiological effects, which have been subject to extensive investigation in diverse experiments. 6-Thioguanosine-5′-O-triphosphate sodium salt finds application in numerous scientific research domains. It has been utilized to examine gene expression, protein synthesis, and signal transduction. Investigations involving 6-Thioguanosine-5′-O-triphosphate sodium salt have shed light on the intricate regulation of gene expression in prokaryotic and eukaryotic cells, as well as in animal models. Additionally, it has contributed to the understanding of protein synthesis regulation and the intricacies of signal transduction pathways. As a signaling molecule, 6-Thioguanosine-5′-O-triphosphate sodium salt is hypothesized to engage with specific DNA sequences, resulting in the activation or repression of gene expression. It is also believed to interact with proteins involved in signal transduction pathways, facilitating the activation or inhibition of specific pathways. Notably, 6-Thioguanosine-5′-O-triphosphate sodium salt exhibits inhibitory properties against GTPase Rac1 activation in T lymphocytes, thereby impeding leukocyte transmigration.